Anti-flavivirus vaccines: review of the present situation and perspectives of subunit vaccines produced in escherichia coli

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dc.contributorLab. Desenvolvimento de Vacinaspt_BR
dc.contributor.authorAraujo, Sergio Carneiropt_BR
dc.contributor.authorPereira, Lennon R.pt_BR
dc.contributor.authorAlves, Rubens P. S.pt_BR
dc.contributor.authorAndreata-Santos, Robertpt_BR
dc.contributor.authorKanno, Alex Issamupt_BR
dc.contributor.authorFerreira, Luis Carlos S.pt_BR
dc.contributor.authorGonçalves, Viviane Maimonipt_BR
dc.date.accessioned2020-09-08T14:14:34Z-
dc.date.available2020-09-08T14:14:34Z-
dc.date.issued2020pt_BR
dc.identifier.citationAraujo SC, Pereira LR., Alves RP.S., Andreata-Santos R, Kanno AI, Ferreira LCS., et al. Anti-flavivirus vaccines: review of the present situation and perspectives of subunit vaccines produced in escherichia coli. Vaccines. 2020 Aug;8(3):492. doi:10.3390/vaccines8030492.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3180-
dc.description.abstractThis article aims to review the present status of anti-flavivirus subunit vaccines, both those at the experimental stage and those already available for clinical use. Aspects regarding development of vaccines to Yellow Fever virus, (YFV), Dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV) are highlighted, with particular emphasis on purified recombinant proteins generated in bacterial cells. Currently licensed anti-flavivirus vaccines are based on inactivated, attenuated, or virus-vector vaccines. However, technological advances in the generation of recombinant antigens with preserved structural and immunological determinants reveal new possibilities for the development of recombinant protein-based vaccine formulations for clinical testing. Furthermore, novel proposals for multi-epitope vaccines and the discovery of new adjuvants and delivery systems that enhance and/or modulate immune responses can pave the way for the development of successful subunit vaccines. Nonetheless, advances in this field require high investments that will probably not raise interest from private pharmaceutical companies and, therefore, will require support by international philanthropic organizations and governments of the countries more severely stricken by these virusespt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.extent492pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofVaccinespt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleAnti-flavivirus vaccines: review of the present situation and perspectives of subunit vaccines produced in escherichia colipt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3390/vaccines8030492pt_BR
dc.identifier.urlhttps://doi.org/10.3390/vaccines8030492pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.identifier.citationvolume8pt_BR
dc.identifier.citationissue3pt_BR
dc.subject.keywordflaviviruspt_BR
dc.subject.keywordmosquito-borne diseasespt_BR
dc.subject.keywordsubunit vaccinespt_BR
dc.relation.ispartofabbreviatedVaccinespt_BR
dc.identifier.citationabntv. 8, n. 3, 492, ago. 2020pt_BR
dc.identifier.citationvancouver2020 Aug;8(3):492pt_BR
dc.contributor.butantanAraujo, Sergio Carneiro|:Aluno|:Laboratório de Desenvolvimento de Vacinas|:PrimeiroAutorpt_BR
dc.contributor.butantanKanno, Alex Issamu|:Aluno|:Laboratório de Desenvolvimento de Vacinaspt_BR
dc.contributor.butantanGonçalves, Viviane Maimoni|:Pesquisador|:Laboratório de Desenvolvimento de Vacinas|:Autor de correspondênciapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦16/20045-7pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦18/24683-3pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦19/18205-4pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦15/02352-7pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦16/23560-0pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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item.languageiso639-1English-
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