Metalloproteinases suppression driven by the curcumin analog DM-1 modulates invasion in BRAF-resistant melanomas

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dc.contributorLab. Fisiopatologiapt_BR
dc.contributor.authorSouza, Nayane dept_BR
dc.contributor.authorOliveira, Érica Aparecida dept_BR
dc.contributor.authorFaião-Flores, Fernandapt_BR
dc.contributor.authorPimenta, Luciana de Araujopt_BR
dc.contributor.authorQuincoces, José A.P.pt_BR
dc.contributor.authorSampaio, Sandra Coccuzzopt_BR
dc.contributor.authorMaria-Engler, Silvya S.pt_BR
dc.date.accessioned2020-09-15T15:01:58Z-
dc.date.available2020-09-15T15:01:58Z-
dc.date.issued2020pt_BR
dc.identifier.citationSouza N, Oliveira EA, Faião-Flores F, Pimenta LA, Quincoces JA.P., Sampaio SC, et al. Metalloproteinases suppression driven by the curcumin analog DM-1 modulates invasion in BRAF-resistant melanomas. Anticancer Agents Med. Chem.. 2020 Jan;20(9):1038-1050. doi:10.2174/1871520620666200218111422.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3190-
dc.description.abstractBackground: Melanoma is the most aggressive skin cancer, and BRAF (V600E) is the most frequent mutation that led to the development of BRAF inhibitors (BRAFi). However, patients treated with BRAFi usually present recidivism after 6-9 months. Curcumin is a turmeric substance, and it has been deeply investigated due to its anti-inflammatory and antitumoral effects. Still, the low bioavailability and biodisponibility encouraged the investigation of different analogs. DM-1 is a curcumin analog and has shown an antitumoral impact in previous studies. Methods: Evaluated DM-1 stability and cytotoxic effects for BRAFi-sensitive and resistant melanomas, as well as the role in the metalloproteinases modulation. Results: DM-1 showed growth inhibitory potential for melanoma cells, demonstrated by reduction of colony formation, migration and endothelial tube formation, and cell cycle arrest. Subtoxic doses were able to downregulate important Metalloproteinases (MMPs) related to invasiveness, such as MMP-1, -2 and -9. Negative modulations of TIMP-2 and MMP-14 reduced MMP-2 and -9 activity; however, the reverse effect is seen when increased TIMP-2 and MMP-14 resulted in raised MMP-2. Conclusion: These findings provide essential details into the functional role of DM-1 in melanomas, encouraging further studies in the development of combinatorial treatments for melanomas.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.format.extent1038 - 1050pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofAnti-Cancer Agents in Medicinal Chemistrypt_BR
dc.titleMetalloproteinases suppression driven by the curcumin analog DM-1 modulates invasion in BRAF-resistant melanomaspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.2174/1871520620666200218111422pt_BR
dc.identifier.urlhttps://doi.org/10.2174/1871520620666200218111422pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.identifier.citationvolume20pt_BR
dc.identifier.citationissue9pt_BR
dc.subject.keywordCurcumin-analoguept_BR
dc.subject.keywordDM-1pt_BR
dc.subject.keywordmelanomapt_BR
dc.subject.keywordBRAF resistancept_BR
dc.subject.keywordvemurafenibpt_BR
dc.subject.keywordBRAF inhibitorpt_BR
dc.relation.ispartofabbreviatedAnticancer Agents Med Chempt_BR
dc.identifier.citationabntv. 20, n. 9, p. 1038-1050, jan. 2020pt_BR
dc.identifier.citationvancouver2020 Jan;20(9):1038-1050pt_BR
dc.contributor.butantanPimenta, Luciana de Araujo|:Aluno|:Lab. Fisiopatologiapt_BR
dc.contributor.butantanSampaio, Sandra Coccuzzo|:Pesquisador:Docente Permanente PPGTOX|:Lab. Fisiopatologiapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/04926-6pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/16554-3pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/05172-4pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)¦¦pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextembargo_29990101-
item.languageiso639-1English-
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