The toxic effects of glyphosate, chlorpyrifos, abamectin, and 2,4‐D on animal models: a systematic review of Brazilian studies

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dc.contributorLaboratório de Toxinologia Aplicadapt_BR
dc.contributorCentro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)pt_BR
dc.contributor.authorDisner, Geonildo Rodrigopt_BR
dc.contributor.authorFalcão, Maria Alice Pimentelpt_BR
dc.contributor.authorAndrade‐Barros, Aline Ingridpt_BR
dc.contributor.authorSantos, Natália Vitorino Leite dospt_BR
dc.contributor.authorSoares, Amanda Beatriz Silvapt_BR
dc.contributor.authorMarcolino-Souza Milenapt_BR
dc.contributor.authorGomes, Kamila de Sousapt_BR
dc.contributor.authorLima, Carlapt_BR
dc.contributor.authorLopes-Ferreira, Monicapt_BR
dc.date.accessioned2020-10-06T20:04:49Z-
dc.date.available2020-10-06T20:04:49Z-
dc.date.issued2020pt_BR
dc.identifier.citationDisner GR, Falcão MAP, Andrade‐Barros AI, Santos NVL, Soares ABS, M-SM, et al. The toxic effects of glyphosate, chlorpyrifos, abamectin, and 2,4‐D on animal models: a systematic review of Brazilian studies. Integr. Environ. Assess. Manag.. 2020 Oct;17(3):507-520. doi:10.1002/ieam.4353.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3264-
dc.description.abstractBrazil is a global agricultural commodity producer and the largest consumer of pesticides. Intern pesticide use comprised 549,280 thousand tons in 2018. In the country, soybean, corn, and sugar cane are extensively produced, which are the most pesticides demanding crops. In the last years, the records of new pesticides were the highest in the historical series. They can persist in soil or water, accumulate in organisms, and contaminate workers and the general population through the air, water, or food. This review aimed to gather toxicological data obtained by animal models exposed to four pesticides: glyphosate, chlorpyrifos, abamectin, and 2,4‐D. Besides, to compose an overview of how this subject has been approached, surveying which research groups are working on this field, where they are located and relations with pesticides used in those regions. We collected the papers from the platforms PubMed, Scopus, Scielo, and Web of Science, performed in Brazil from 2014 to 2019. After two‐step blind selection using the software Rayyan QCRI by different authors, 67 studies were selected to extract data. We observed that research is more concentrated in the South region, followed by the Southeast and Midwest, with 43, 32, and 23% of the studies, respectively. The prevalent institutions are from the states of Rio Grande do Sul, São Paulo, and Goiás. The effects on a variety of biomarkers help predict the potential risks in humans and non‐target organisms. The prevalent animal model was fish (36%). Overall, the main toxic effects evaluated were mortality, abnormalities in the blood cells, developmental abnormalities, and behavior alterations.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofIntegrated Environmental Assessment and Managementpt_BR
dc.rightsRestricted accesspt_BR
dc.titleThe toxic effects of glyphosate, chlorpyrifos, abamectin, and 2,4‐D on animal models: a systematic review of Brazilian studiespt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1002/ieam.4353pt_BR
dc.identifier.urlhttps://doi.org/10.1002/ieam.4353pt_BR
dc.identifier.citationvolume17pt_BR
dc.identifier.citationissue3pt_BR
dc.subject.keywordPesticidespt_BR
dc.subject.keywordToxicitypt_BR
dc.subject.keywordGenotoxicpt_BR
dc.subject.keywordExperimental animal modelspt_BR
dc.subject.keywordBrazilian researcherspt_BR
dc.relation.ispartofabbreviatedIntegr. Environ. Assess. Manag.pt_BR
dc.identifier.citationabntv. 17, n. 3, p. 507-520, out. 2020pt_BR
dc.identifier.citationvancouver2020 Oct;17(3):507-520pt_BR
dc.contributor.butantanDisner, Geonildo Rodrigo|:Pesquisador|:Laboratório de Toxinologia Aplicada:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)|:PrimeiroAutorpt_BR
dc.contributor.butantanFalcão, Maria Alice Pimentel|:Aluno|:Laboratório de Toxinologia Aplicada:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICSpt_BR
dc.contributor.butantanAndrade‐Barros, Aline Ingrid|:Técnico|:Laboratório de Toxinologia Aplicada:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICSpt_BR
dc.contributor.butantanSantos, Natália Vitorino Leite dos|:Técnico|:Laboratório de Toxinologia Aplicada:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICSpt_BR
dc.contributor.butantanSoares, Amanda Beatriz Silva|:Laboratório de Toxinologia Aplicada:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICSpt_BR
dc.contributor.butantanMarcolino-Souza Milena|:Aluno|:Laboratório de Toxinologia Aplicada:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICSpt_BR
dc.contributor.butantanGomes, Kamila de Sousa|:Aluno|:Laboratório de Toxinologia Aplicada:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICSpt_BR
dc.contributor.butantanLima, Carla|:Pesquisador:Docente permanente PPGTOX|:Laboratório de Toxinologia Aplicada:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICSpt_BR
dc.contributor.butantanLopes-Ferreira, Mônica|:Pesquisador:Docente permanente PPGTOX|:Laboratório de Toxinologia Aplicada:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS|:Autor de correspondênciapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
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