Tick salivary compounds for targeted immunomodulatory therapy

Full metadata record
DC FieldValueLanguage
dc.contributorLab. Desenvolvimento e Inovação Industrialpt_BR
dc.contributorLab. Biologia Molecularpt_BR
dc.contributor.authorAounallah, Hajerpt_BR
dc.contributor.authorBensaoud, Chaimapt_BR
dc.contributor.authorM’ghirbi, Youmnapt_BR
dc.contributor.authorFaria, Fernandapt_BR
dc.contributor.authorChmelar̆, Jindr̆ichpt_BR
dc.contributor.authorKotsyfakis, Michailpt_BR
dc.date.accessioned2020-10-22T18:39:22Z-
dc.date.available2020-10-22T18:39:22Z-
dc.date.issued2020pt_BR
dc.identifier.citationAounallah H, Bensaoud C, M’ghirbi Y, Faria F, Chmelar̆ J, Kotsyfakis M. Tick salivary compounds for targeted immunomodulatory therapy. Front. Immunol.. 2020 Sept;11:583845. doi:10.3389/fimmu.2020.583845.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3276-
dc.description.abstractImmunodeficiency disorders and autoimmune diseases are common, but a lack of effective targeted drugs and the side-effects of existing drugs have stimulated interest in finding therapeutic alternatives. Naturally derived substances are a recognized source of novel drugs, and tick saliva is increasingly recognized as a rich source of bioactive molecules with specific functions. Ticks use their saliva to overcome the innate and adaptive host immune systems. Their saliva is a rich cocktail of molecules including proteins, peptides, lipid derivatives, and recently discovered non-coding RNAs that inhibit or modulate vertebrate immune reactions. A number of tick saliva and/or salivary gland molecules have been characterized and shown to be promising candidates for drug development for vertebrate immune diseases. However, further validation of these molecules at the molecular, cellular, and organism levels is now required to progress lead candidates to clinical testing. In this paper, we review the data on the immuno-pharmacological aspects of tick salivary compounds characterized in vitro and/or in vivo and present recent findings on non-coding RNAs that might be exploitable as immunomodulatory therapies.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipThe Czech Science Foundation (GACR)pt_BR
dc.format.extent583845pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofFrontiers in Immunologypt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleTick salivary compounds for targeted immunomodulatory therapypt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3389/fimmu.2020.583845pt_BR
dc.identifier.urlhttps://doi.org/10.3389/fimmu.2020.583845pt_BR
dc.contributor.externalUniversité de Tunis El Manarpt_BR
dc.contributor.externalCzech Academy of Sciencespt_BR
dc.contributor.externalUniversity of South Bohemia České Budějovicept_BR
dc.identifier.citationvolume11pt_BR
dc.subject.keywordtick salivapt_BR
dc.subject.keywordsalivary glandspt_BR
dc.subject.keywordhost immunitypt_BR
dc.subject.keywordimmunomodulationpt_BR
dc.subject.keyworddrug discoverypt_BR
dc.relation.ispartofabbreviatedFront Immunolpt_BR
dc.identifier.citationvancouver2020 Sept;11:583845pt_BR
dc.contributor.butantanAounallah, Hajer|:Aluno|:Lab. Desenvolvimento e Inovação Industrial|:PrimeiroAutorpt_BR
dc.contributor.butantanFaria, Fernanda|:Pesquisador:Docente colaborador PPGTOX|:Lab. Desenvolvimento e Inovação Industrial:Lab. Biologia Molecular|pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦001pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07467–1pt_BR
dc.sponsorship.butantanThe Czech Science Foundation (GACR)¦¦19-382 07247Spt_BR
dc.sponsorship.butantanThe Czech Science Foundation (GACR)¦¦19-14704Ypt_BR
dc.sponsorship.butantanThe Czech Science Foundation (GACR)¦¦384 CZ.02.1.01/0.0/0.0/16_019/0000759pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
item.fulltextCom Texto completo-
item.openairetypeArticle-
item.grantfulltextopen-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid0000-0001-6993-6323-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journalissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journaleissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
Appears in Collections:Artigos de periódicos


Files in This Item:

10.3389fimmu.2020.583845.pdf
Description:
Size: 2.53 MB
Format: Adobe PDF
View/Open
Show simple item record

This item is licensed under a Creative Commons License Creative Commons