Chemokine expression profiles in liver and kidney of mice with different susceptibilities to leptospirosis

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dc.contributorLaboratório de Bacteriologiapt_BR
dc.contributorLaboratório Piloto de Recombinantespt_BR
dc.contributorDivisão Bioindustrialpt_BR
dc.contributor.authorSilva, Paloma Luiza Duarte dapt_BR
dc.contributor.authorNakajima, Erikapt_BR
dc.contributor.authorCosta, Renata M. A. dapt_BR
dc.contributor.authorHo, Paulo Leept_BR
dc.contributor.authorMartins, Elizabeth Angelica Lemept_BR
dc.contributor.authorCarvalho, Eneaspt_BR
dc.contributor.authorSilva, Josefa Bezerra dapt_BR
dc.date.accessioned2020-10-27T13:21:03Z-
dc.date.available2020-10-27T13:21:03Z-
dc.date.issued2020-
dc.identifier.citationSilva PLD, Nakajima E, Costa RM.A., Ho PL, Martins EAL, Carvalho E, et al. Chemokine expression profiles in liver and kidney of mice with different susceptibilities to leptospirosis. Microb. Pathog.. 2020 Dec;149:104580. doi:10.1016/j.micpath.2020.104580.pt_BR
dc.identifier.issn0882-4010-
dc.identifier.issn1096-1208-
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3285-
dc.description.abstractLeptospirosis is a global disease that affects humans and animals, impacting public health and the economy. The symptoms caused by Leptospira infection can vary from mild to severe, affecting liver, lungs, and kidneys. The host-pathogen interaction in leptospirosis is still poorly understood, but there is evidence for the role of the host immune response in the pathogenesis. Chemokines are a family of structurally-related low-molecular-mass proteins (8–14 kDa) that signal the recruitment of leukocytes. In this study the profile of 22 chemokines were evaluated in liver and kidney of three mice strains with different phenotypes of susceptibility to leptospirosis. We extended our previously reported observations showing that expression of chemokines with homeostatic function, activation and chemotaxis of leukocytes are essential to modulate and to induce resistance to leptospirosis. Our findings support that an early induction of CXC chemokines in resistant BALB/c mice can be associated with the control of the infection. The correlation of chemokine expression between liver and kidney observed in BALB/c suggests that a balance of chemokine induction in the organs may contribute to resistance to leptospirosis.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipFundação Butantanpt_BR
dc.format.extent104580pt_BR
dc.languageengpt_BR
dc.publisherAcademic Presspt_BR
dc.relation.ispartofMicrobial Pathogenesispt_BR
dc.titleChemokine expression profiles in liver and kidney of mice with different susceptibilities to leptospirosispt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.micpath.2020.104580-
dc.identifier.urlhttps://doi.org/10.1016/j.micpath.2020.104580-
dc.contributor.externalDrugs for Neglected Diseases Initiative (DNDi)pt_BR
dc.publisher.cityLondonpt_BR
dc.identifier.citationvolume149-
dc.subject.keywordChemokinespt_BR
dc.subject.keywordC3H/HeJ micept_BR
dc.subject.keywordBALB/cpt_BR
dc.subject.keywordLeptospirapt_BR
dc.subject.keywordLiverpt_BR
dc.subject.keywordKidneypt_BR
dc.subject.keywordLeptospirosispt_BR
dc.relation.ispartofabbreviatedMicrob. Pathog.pt_BR
dc.identifier.citationabntv. 149, 104580, dez. 2020-
dc.identifier.citationvancouver2020 Dec;149:104580-
dc.publisher.countryEnglandpt_BR
dc.contributor.butantanSilva, Paloma Luiza Duarte da|:Aluno|:Laboratório de Bacteriologia|:PrimeiroAutorpt_BR
dc.contributor.butantanNakajima, Erika|:Técnico|:Laboratório Piloto de Recombinantespt_BR
dc.contributor.butantanHo Lee, Paulo|:Pesquisador|:Divisão Bioindustrialpt_BR
dc.contributor.butantanMartins, Elizabeth Angelica Leme|:Laboratório Piloto de Recombinantespt_BR
dc.contributor.butantanCarvalho, Eneas|:Pesquisador|:Laboratório de Bacteriologiapt_BR
dc.contributor.butantanDa Silva, Josefa Bezerra|:Pesquisador|:Laboratório de Bacteriologiapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/16451–1pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/20903-6pt_BR
dc.identifier.bvsccBR78.1-
dc.identifier.bvsdbBR78.1-
item.openairetypeArticle-
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item.grantfulltextnone-
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