Structural analysis of CACHE domain of the McpA chemoreceptor from Leptospira interrogans

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dc.contributorLaboratório Especial de Desenvolvimento de Vacinas (LEDV)pt_BR
dc.contributor.authorSantos, Jademilson Celestino dospt_BR
dc.contributor.authorVieira, Mônica L.pt_BR
dc.contributor.authorAbendroth, Janpt_BR
dc.contributor.authorLin, Taopt_BR
dc.contributor.authorStaker, Bart L.pt_BR
dc.contributor.authorMyler, Peter J.pt_BR
dc.contributor.authorNascimento, Ana Lúcia Tabet Oller dopt_BR
dc.date.accessioned2020-10-27T19:56:26Z-
dc.date.available2020-10-27T19:56:26Z-
dc.date.issued2020-
dc.identifier.citationSantos JC, Vieira ML., Abendroth J, Lin T, Staker BL., Myler PJ., et al. Structural analysis of CACHE domain of the McpA chemoreceptor from Leptospira interrogans. Mol. Cell. Biol. Res. Commun.. 2020 Oct;in press. doi:10.1016/j.bbrc.2020.10.013.pt_BR
dc.identifier.issn1522-4724-
dc.identifier.issn1522-4732-
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3289-
dc.description.abstractLeptospira is a genus of spirochete bacteria highly motile that includes pathogenic species responsible to cause leptospirosis disease. Chemotaxis and motility are required for Leptospira infectivity, pathogenesis, and invasion of bacteria into the host. In prokaryotes, the most common chemoreceptors are methyl-accepting chemotaxis proteins that have a role play to detect the chemical signals and move to a favorable environment for its survival. Here, we report the first crystal structure of CACHE domain of the methyl-accepting chemotaxis protein (McpA) of L. interrogans. The structural analysis showed that McpA adopts similar α/β architecture of several other bacteria chemoreceptors. We also found a typical dimerization interface that appears to be functionally crucial for signal transmission and chemotaxis. In addition to McpA structural analyses, we have identified homologous proteins and conservative functional regions using bioinformatics techniques. These results improve our understanding the relationship between chemoreceptor structures and functions of Leptospira species.pt_BR
dc.description.sponsorshipNational Institutes of Health (NIH)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.languageengpt_BR
dc.publisherAcademic Presspt_BR
dc.relation.ispartofMolecular Cell Biology Research Communicationspt_BR
dc.titleStructural analysis of CACHE domain of the McpA chemoreceptor from Leptospira interroganspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.bbrc.2020.10.013-
dc.identifier.urlhttps://doi.org/10.1016/j.bbrc.2020.10.013-
dc.contributor.externalUniversidade Federal de Minas Gerais (UFMG)pt_BR
dc.contributor.externalUCB Pharma SApt_BR
dc.contributor.externalSeattle Structural Genomics Center for Infectious Disease (SSGCID)pt_BR
dc.contributor.externalBaylor College of Medicinept_BR
dc.contributor.externalSeattle Children’s Research Institutept_BR
dc.contributor.externalUniversity of Washington (UW)pt_BR
dc.publisher.citySan Diegopt_BR
dc.subject.keywordLeptospira interroganspt_BR
dc.subject.keywordBacterial chemoreceptorpt_BR
dc.subject.keywordChemotaxispt_BR
dc.subject.keywordCrystal structurept_BR
dc.subject.keywordCACHE domainpt_BR
dc.subject.keywordMcpApt_BR
dc.relation.ispartofabbreviatedMol. Cell. Biol. Res. Commun.pt_BR
dc.identifier.citationabntin press, out. 2020-
dc.identifier.citationvancouver2020 Oct;in press-
dc.publisher.countryUnited Statespt_BR
dc.contributor.butantanSantos, Jademilson Celestino dos|:Aluno|:Laboratório Especial de Desenvolvimento de Vacinas (LEDV)|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanNascimento, Ana Lúcia Tabet Oller do|:Pesquisador|:Laboratório Especial de Desenvolvimento de Vacinas (LEDV)pt_BR
dc.sponsorship.butantanNational Institutes of Health (NIH)¦¦HHSN272201700059Cpt_BR
dc.sponsorship.butantanNational Institutes of Health (NIH)¦¦HHSN272201200025Cpt_BR
dc.sponsorship.butantanNational Institutes of Health (NIH)¦¦HHSN272200700057Cpt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/25167-6pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/50981-0pt_BR
dc.identifier.bvsccBR78.1-
dc.identifier.bvsdbIBProd-
item.openairetypeArticle-
item.fulltextSem Texto completo-
item.grantfulltextnone-
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