Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics

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dc.contributorLaboratório de Imunoquímicapt_BR
dc.contributor.authorNani, João V.pt_BR
dc.contributor.authorLee, Richard S.pt_BR
dc.contributor.authorYonamine, Camila M.pt_BR
dc.contributor.authorSant'Anna, Osvaldo Augustopt_BR
dc.contributor.authorJuliano, Maria A.pt_BR
dc.contributor.authorGadelha, Arypt_BR
dc.contributor.authorMari, Jair J.pt_BR
dc.contributor.authorHayashi, Mirian A. F.pt_BR
dc.date.accessioned2020-11-04T14:59:10Z-
dc.date.available2020-11-04T14:59:10Z-
dc.date.issued2020-
dc.identifier.citationNani JV., Lee RS., Yonamine CM., Sant'Anna OA, Juliano MA., Gadelha A, et al. Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics. Sci. Rep.. 2020 Oct;10:18513. doi:10.1038/s41598-020-75616-2.pt_BR
dc.identifier.issn2045-2322-
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3297-
dc.description.abstractNuclear distribution element-like 1 (NDEL1) enzyme activity is important for neuritogenesis, neuronal migration, and neurodevelopment. We reported previously lower NDEL1 enzyme activity in blood of treated first episode psychosis and chronic schizophrenia (SCZ) compared to healthy control subjects, with even lower activity in treatment resistant chronic SCZ patients, implicating NDEL1 activity in SCZ. Herein, higher NDEL1 activity was observed in the blood and several brain regions of a validated animal model for SCZ at baseline. In addition, long-term treatment with typical or atypical antipsychotics, under conditions in which SCZ-like phenotypes were reported to be reversed in this animal model for SCZ, showed a significant NDEL1 activity reduction in blood and brain regions which is in line with clinical data. Importantly, these results support measuring NDEL1 enzyme activity in the peripheral blood to predict changes in NDEL1 activity in the CNS. Also, acute administration of psychostimulants, at levels reported to induce SCZ-like phenotype in normal rat strains, increased NDEL1 enzyme activity in blood. Therefore, alterations in NDEL1 activity after treatment with antipsychotics or psychostimulants may suggest a possible modulation of NDEL1 activity secondary to neurotransmission homeostasis and provide new insights into the role of NDEL1 in SCZ pathophysiology.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.format.extent18513pt_BR
dc.languageengpt_BR
dc.publisherNature Publishing Grouppt_BR
dc.relation.ispartofScientific Reportspt_BR
dc.rightsOpen Accesspt_BR
dc.titleEvaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophreniapt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1038/s41598-020-75616-2-
dc.identifier.urlhttps://doi.org/10.1038/s41598-020-75616-2-
dc.contributor.externalUniversidade Federal de São Paulo (UNIFESP)pt_BR
dc.contributor.externalNational Institute for Translational Medicine (INCT-TM)pt_BR
dc.contributor.externalJohns Hopkins University (JHU)pt_BR
dc.title.subeffects of psychostimulants and antipsychoticspt_BR
dc.publisher.cityLondonpt_BR
dc.identifier.citationvolume10-
dc.subject.keywordBiochemistrypt_BR
dc.subject.keywordDiseases of the nervous systempt_BR
dc.subject.keywordEnzymespt_BR
dc.subject.keywordNeurosciencept_BR
dc.subject.keywordSchizophreniapt_BR
dc.relation.ispartofabbreviatedSci. Rep.pt_BR
dc.identifier.citationabntv. 10, 18513, out. 2020-
dc.identifier.citationvancouver2020 Oct;10:18513-
dc.publisher.countryEnglandpt_BR
dc.contributor.butantanSant'anna, Osvaldo Augusto|:Pesquisador|:Laboratório de Imunoquímicapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2019/09207-3pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2012/50191-4pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/13392-4pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/02413-1pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦477760/2010-4pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦557753/2010-4pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦508113/2010-5pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦311815/2012-0pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦475739/2013-2pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦311815/2012-0pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦309337/2016-0pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦pt_BR
dc.identifier.bvsccBR78.1-
dc.identifier.bvsdbIBProd-
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