Novel biotechnological approaches for monitoring and immunization against resistant to antibiotics Escherichia coli and other pathogenic bacteria

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dc.contributorLaboratório de Genéticapt_BR
dc.contributor.authorBelizário, José E.pt_BR
dc.contributor.authorSircili, Marcelo Palmapt_BR
dc.date.accessioned2020-11-10T19:32:07Z-
dc.date.available2020-11-10T19:32:07Z-
dc.date.issued2020-
dc.identifier.citationBelizário JE., Sircili MP. Novel biotechnological approaches for monitoring and immunization against resistant to antibiotics Escherichia coli and other pathogenic bacteria. BMC Vet. Res.. 2020 Nov;16:420. doi:10.1186/s12917-020-02633-8.pt_BR
dc.identifier.issn1746-6148-
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3300-
dc.description.abstractThe application of next-generation molecular, biochemical and immunological methods for developing new vaccines, antimicrobial compounds, probiotics and prebiotics for zoonotic infection control has been fundamental to the understanding and preservation of the symbiotic relationship between animals and humans. With increasing rates of antibiotic use, resistant bacterial infections have become more difficult to diagnose, treat, and eradicate, thereby elevating the importance of surveillance and prevention programs. Effective surveillance relies on the availability of rapid, cost-effective methods to monitor pathogenic bacterial isolates. In this opinion article, we summarize the results of some research program initiatives for the improvement of live vaccines against avian enterotoxigenic Escherichia coli using virulence factor gene deletion and engineered vaccine vectors based on probiotics. We also describe methods for the detection of pathogenic bacterial strains in eco-environmental headspace and aerosols, as well as samples of animal and human breath, based on the composition of volatile organic compounds and fatty acid methyl esters. We explain how the introduction of these low-cost biotechnologies and protocols will provide the opportunity to enhance co-operation between networks of resistance surveillance programs and integrated routine workflows of veterinary and clinical public health microbiology laboratories.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.format.extent420pt_BR
dc.languageengpt_BR
dc.publisherBiomed Centralpt_BR
dc.relation.ispartofBMC Veterinary Researchpt_BR
dc.rightsOpen Accesspt_BR
dc.titleNovel biotechnological approaches for monitoring and immunization against resistant to antibiotics Escherichia coli and other pathogenic bacteriapt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1186/s12917-020-02633-8-
dc.identifier.urlhttps://doi.org/10.1186/s12917-020-02633-8-
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.publisher.cityLondonpt_BR
dc.identifier.citationvolume16-
dc.subject.keywordBacterial vaccinespt_BR
dc.subject.keywordMicrobiomespt_BR
dc.subject.keywordProbioticspt_BR
dc.subject.keywordAntibioticspt_BR
dc.subject.keywordVOCspt_BR
dc.subject.keywordAnd FAMEspt_BR
dc.relation.ispartofabbreviatedBMC Vet. Res.pt_BR
dc.identifier.citationabntv. 16, 420, nov. 2020-
dc.identifier.citationvancouver2020 Nov;16:420-
dc.publisher.countryEnglandpt_BR
dc.contributor.butantanSircili, Marcelo Palma|:Pesquisador|:Laboratório de Genéticapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦486048/2011pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦312206/2016–0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2012/02497–7pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/20847–0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2010/06707–0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2008/05519–6pt_BR
dc.identifier.bvsccBR78.1-
dc.identifier.bvsdbIBProd-
item.openairetypeArticle-
item.fulltextSem Texto completo-
item.grantfulltextnone-
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