Uso de compostos químicos capazes de inibir a ação tóxica das esfingomielinases do veneno de aranhas loxosceles e composição farmacêutica compreendendo os referidos compostos

Abstract

Use of chemical compounds capable of inhibiting the toxic action of sphingomyelinases d from the venom of loxosceles spiders and a pharmaceutical composition comprising said compounds the present invention preferably refers to the use of 4-bromo-n-[(e)-(2- methyl-1h-indol-3-yl)methyleneamino]benzenesulfonamide and 4-methyl-3-oxo-2-(3-pyridylmethylene)benzo[3,4-b]furan-6-yl-4-chlorobenzenesulfonate, (compounds 5 and 6, respectively), which are compounds capable of inhibiting the toxic action of sphingomyelinases d from loxosceles venom, controlling the development of cutaneous and systemic loxoscelism; reduction of hemolysis, inhibit skin injury, inhibit dermonecrosis, inhibit intracellular signaling pathways and production of reactive oxygen species. In addition to the therapeutic potential, such inhibitors can be used as tools in the study of the action of sphingomyelinases and phospholipases d. The present invention further relates to a pharmaceutical composition for treating loxoscelism, reducing hemolysis, inhibiting skin damage, inhibiting dermonecrosis, inhibiting intracellular signaling pathways and producing reactive oxygen species, which comprises said compounds and a pharmaceutically acceptable vehicle.