Meningitis caused by Streptococcus agalactiae in nile tilapia (Oreochromis niloticus): infection and inflammatory response

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dc.contributorLab. Imunoquímicapt_BR
dc.contributor.authorEto, Silas Fernandespt_BR
dc.contributor.authorFernandes, Dayanne Carlapt_BR
dc.contributor.authorMoraes, Alessandra Cristina dept_BR
dc.contributor.authorFernandes, Dayanne Carlapt_BR
dc.contributor.authorAlecrim, João Victor da Costapt_BR
dc.contributor.authorSouza, Pedro Galdino dept_BR
dc.contributor.authorCarvalho, Fabíola Christian Almeida dept_BR
dc.contributor.authorCharlie-Silva, Ivespt_BR
dc.contributor.authorBelo, Marco Antonio de Andradept_BR
dc.contributor.authorPizauro, João Martinspt_BR
dc.date.accessioned2020-12-15T16:46:17Z-
dc.date.available2020-12-15T16:46:17Z-
dc.date.issued2020pt_BR
dc.identifier.citationEto SF, Fernandes DC, Moraes AC, Fernandes DC, Alecrim JVC, Souza PG, et al. Meningitis caused by Streptococcus agalactiae in nile tilapia (Oreochromis niloticus): infection and inflammatory response. Animals. 2020 Nov;10(11):2166. doi:10.3390/ani10112166.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3366-
dc.description.abstractStreptococcus agalactiae (Sta) of Lancefield group B is the primary etiological agent of bacterial meningitis in Nile tilapia and newborn humans. Thus, the study of this disease is of fundamental importance for aquaculture and human medicine. Additionally, elucidation of the mechanisms involved in the host–pathogenic response is important for the success of new therapies. In the present study, we elucidated important aspects of the innate immune response in the brain tissue of Nile tilapia (Oreochromis niloticus) infected by Sta. The neuroinflammatory process in the meninges started with the migration of MHC class II and CD68 + cells, production of TNF-alpha, and the effective immune response to Sta was mediated by the increased iNOs+. In conclusion, the present study brings a partial understanding of the pathophysiological and neuroinflammatory mechanisms in meningitis in Sta infected tilapia, enabling important advances in the therapy of this disease as well as the possibility of using this biological model to understand human meningitis.pt_BR
dc.format.extent2166pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofAnimalspt_BR
dc.rightsOpen Accesspt_BR
dc.titleMeningitis caused by Streptococcus agalactiae in nile tilapia (Oreochromis niloticus): infection and inflammatory responsept_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/ani10112166pt_BR
dc.identifier.urlhttps://doi.org/10.3390/ani10112166pt_BR
dc.contributor.externalUniversidade Federal de Roraima (UFRR)pt_BR
dc.contributor.externalUniversidade Federal de Rondônia (UNIR)pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.contributor.externalUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP)pt_BR
dc.contributor.externalUniversidade Brasilpt_BR
dc.identifier.citationvolume10pt_BR
dc.identifier.citationissue11pt_BR
dc.subject.keywordstreptococcosispt_BR
dc.subject.keywordmicrogliapt_BR
dc.subject.keywordteleost fishpt_BR
dc.subject.keywordneuropathypt_BR
dc.relation.ispartofabbreviatedAnimalspt_BR
dc.identifier.citationabntv. 10, n. 11, 2166, nov. 2020pt_BR
dc.identifier.citationvancouver2020 Nov;10(11):2166pt_BR
dc.contributor.butantanFernandes, Dayanne Carla|:Aluno|:Lab. Imunoquímicapt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
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item.languageiso639-1English-
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