Antimicrobial effect of bothropstoxin-i in broilers

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dc.contributor.authorSilveira, Ana Carolina Portellapt_BR
dc.contributor.authorGimenes, Sarah Natalie Cirilopt_BR
dc.contributor.authorBarbaresco, Luiz Fernandopt_BR
dc.contributor.authorCarvalho, Camila Perdoncinipt_BR
dc.contributor.authorBueno, João Paulo Rodriguespt_BR
dc.contributor.authorGuimarães, Ednaldo Carvalhopt_BR
dc.contributor.authorFreitas, Paulo Fernando Alves dept_BR
dc.contributor.authorNascimento, Mara Regina Bueno de Mattospt_BR
dc.contributor.authorAntunes, Robson Carlospt_BR
dc.contributor.authorÁvila, Veridiana de Melo Rodriguespt_BR
dc.date.accessioned2020-12-21T18:09:29Z-
dc.date.available2020-12-21T18:09:29Z-
dc.date.issued2021pt_BR
dc.identifier.citationSilveira ACP, Gimenes SNC, Barbaresco LF, Carvalho CP, Bueno JPR, Guimarães EC, et al. Antimicrobial effect of bothropstoxin-i in broilers. Semin. Cienc. Agrar.. 2021 Jan/Fev;42(1):267-282. doi:10.5433/1679-0359.2021v42n1p267.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3417-
dc.description.abstractBacterial resistance is a sanitary issue explained by indiscriminate use of nonprescription drugs, and antimicrobial use in food production for growth promotion. Bothropstoxin-I (BthTx-I) is a phospholipase A2 (PLA2) from Bothrops jararacussu venom, which has a known antimicrobial effect. The goal of this study was the unprecedented evaluation of in vivo antimicrobial activity of BthTx-I in broilers. Microbiological, biochemical, and histological parameters were determined using 84 21-day old broilers that were kept in cages with four birds each at a density of 625 cm2/broiler. The experiment was randomized by three treatments with seven repetitions of four broilers each that lasted seven days. The treatments were: 1) bacitracin zinc diet; 2) PLA2-BthTx-I; 3) without additives. The data obtained from the studied variables was subjected to analysis of variance and an F-test at the 5% significance level. Averages of each variable in each treatment were compared by Tukey’s test. Broiler bacterial cloacal counts showed that BthTx-I decreased the microbial population without reducing body weight, intestinal morphology, or liver or kidney histopathological damage. The toxin showed in vivo activity, being an alternative for better performance in the production of broiler chickens, because it acted by decreasing the microbial load of potentially pathogenic bacteria in the intestinal microbiota of the birds and did not cause muscle, liver or kidney damage at the assessed dosage.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipUniversidade Federal de Uberlândia (UFU)pt_BR
dc.format.extent267-282pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofSemina. Ciências agráriaspt_BR
dc.titleAntimicrobial effect of bothropstoxin-i in broilerspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.5433/1679-0359.2021v42n1p267pt_BR
dc.identifier.urlhttp://dx.doi.org/10.5433/1679-0359.2021v42n1p267pt_BR
dc.contributor.externalInstituto Federal do Triângulo Mineiro (IFTM)pt_BR
dc.contributor.externalFaculdade Pitágoraspt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.contributor.externalCentro Universitário do Triângulo (UNITRI)pt_BR
dc.contributor.externalUniversidade Federal de Uberlândia (UFU)pt_BR
dc.contributor.externalYes Nutritionpt_BR
dc.identifier.citationvolume42pt_BR
dc.identifier.citationissue1pt_BR
dc.subject.keywordBiochemistrypt_BR
dc.subject.keywordBothrops jararacussupt_BR
dc.subject.keywordNutritionpt_BR
dc.subject.keywordPhospholipase A2pt_BR
dc.subject.keywordPoultrypt_BR
dc.subject.keywordSnake venompt_BR
dc.relation.ispartofabbreviatedSemin Cienc Agrarpt_BR
dc.identifier.citationabntv. 42, n. 1, p. 267-282, jan./fev. 2021pt_BR
dc.identifier.citationvancouver2021 Jan/Fev;42(1):267-282pt_BR
dc.contributor.butantanGimenes, Sarah Natalie Cirilo|:Aluno|:pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦pt_BR
dc.sponsorship.butantanUniversidade Federal de Uberlândia (UFU)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
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item.grantfulltextembargo_29990101-
item.languageiso639-1English-
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