Searching for the toxic potential of Loxosceles amazonica and Loxosceles willianilsoni spiders’ venoms

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dc.contributorLab. Imunoquímicapt_BR
dc.contributorLaboratório de Ecologia e Evoluçãopt_BR
dc.contributor.authorLopes, Priscila Hesspt_BR
dc.contributor.authorFukushima, Caroline Sayuript_BR
dc.contributor.authorShoji, Rosana de Fátimapt_BR
dc.contributor.authorTambourgi, Denise Vilarinhopt_BR
dc.date.accessioned2021-01-05T13:32:12Z-
dc.date.available2021-01-05T13:32:12Z-
dc.date.issued2021pt_BR
dc.identifier.citationLopes PH, Fukushima CS, Shoji RF, Tambourgi DV. Searching for the toxic potential of Loxosceles amazonica and Loxosceles willianilsoni spiders’ venoms. Toxicon. 2020 Feb;191:1-8. doi:10.1016/j.toxicon.2020.12.006.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3426-
dc.description.abstractThe Loxosceles genus belongs to the Sicariidae family and it comprises species whose venom can cause accidents with potentially fatal consequences. We have previously shown that SMase D is the enzyme responsible for the main pathological effects of Loxosceles venom. Despite the severity of accidents with Loxosceles, few species are considered to be of medical importance. Little is known about the venom of non-synanthropic species that live in natural environments. To contribute to a better understanding about the venom's toxicity of Loxosceles genus, the aim of this study was to (i) characterize the toxic properties of Loxosceles amazonica from two different localities and a recent described cave species Loxosceles willianilsoni and (ii) compare these venoms with that from Loxosceles laeta, which is among the most toxic ones. We show here that both L. amazonica venoms (from the two studied locations) and L. willianilsoni presented SMase D activity similar to that exhibited by L. laeta venom. Although L. amazonica and L. willianilsoni venoms were able to induce complement dependent human erythrocytes lysis, they were not able to induce cell death of human keratinocytes, as promoted by L. laeta venom, in the concentrations tested. These results indicate that other species of Loxosceles, in addition to those classified as medically important, have toxic potential to cause accidents in humans, despite interspecific variations that denote possible less toxicity.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipKone Foundationpt_BR
dc.format.extent1-8pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxiconpt_BR
dc.titleSearching for the toxic potential of Loxosceles amazonica and Loxosceles willianilsoni spiders’ venomspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.toxicon.2020.12.006pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.toxicon.2020.12.006pt_BR
dc.contributor.externalUniversity of Helsinkipt_BR
dc.identifier.citationvolume191pt_BR
dc.subject.keywordLoxosceles speciespt_BR
dc.subject.keywordSpiderspt_BR
dc.subject.keywordSphingomyelinase Dpt_BR
dc.subject.keywordHemolysispt_BR
dc.subject.keywordKeratinocytespt_BR
dc.subject.keywordVenoms variationspt_BR
dc.relation.ispartofabbreviatedToxiconpt_BR
dc.identifier.citationabntv. 191, p. 1-8, fev. 2020pt_BR
dc.identifier.citationvancouver2020 Feb;191:1-8pt_BR
dc.contributor.butantanLopes, Priscila Hess|:Aluno|:Lab. Imunoquímica|:PrimeiroAutorpt_BR
dc.contributor.butantanFukushima, Caroline Sayuri|:Aluno|:Laboratório de Ecologia e Evoluçãopt_BR
dc.contributor.butantanShoji, Rosana de Fátima|:Técnico|:Lab. Imunoquímicapt_BR
dc.contributor.butantanBertani, Rogério|:Pesquisador|:Laboratório de Ecologia e Evoluçãopt_BR
dc.contributor.butantanTambourgi, Denise Vilarinho|:Pesquisador:Docente Permanente PPGTOX|:Lab. Imunoquímica|:Autor de correspondênciapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07467–1pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/17053–5pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦301358/2017–6pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦307704/2017–3pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦23038.00814/2011–83pt_BR
dc.sponsorship.butantanKone Foundation¦¦2018pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
item.fulltextSem Texto completo-
item.openairetypeArticle-
item.grantfulltextnone-
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