Electrical stimulation of the posterior insula induces mechanical analgesia in a rodent model of neuropathic pain by modulating GABAergic signaling and activity in the pain circuitry

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dc.contributorLab. Bioquímicapt_BR
dc.contributor.authorAlonso-Matielo, Heloísapt_BR
dc.contributor.authorGonçalves, Elizamara S.pt_BR
dc.contributor.authorCampos, Marianapt_BR
dc.contributor.authorOliveira, Victória R.S.pt_BR
dc.contributor.authorToniolo, Elaine F.pt_BR
dc.contributor.authorAlves, Adilson S.pt_BR
dc.contributor.authorLebrun, Ivopt_BR
dc.contributor.authorAndrade, Daniel C. dept_BR
dc.contributor.authorTeixeira, Manoel J.pt_BR
dc.contributor.authorBritto, Luiz R.G.pt_BR
dc.contributor.authorClement Hamanipt_BR
dc.contributor.authorDale, Camila S.pt_BR
dc.date.accessioned2021-01-08T14:40:01Z-
dc.date.available2021-01-08T14:40:01Z-
dc.date.issued2021pt_BR
dc.identifier.citationAlonso-Matielo H, Gonçalves ES., Campos M, Oliveira VR.S., Toniolo EF., Alves AS., et al. Electrical stimulation of the posterior insula induces mechanical analgesia in a rodent model of neuropathic pain by modulating GABAergic signaling and activity in the pain circuitry. Brain Res.. 2021 Jan;1754:147237. doi:10.1016/j.brainres.2020.147237.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3433-
dc.description.abstractThe insula has emerged as a critical target for electrical stimulation since it influences pathological pain states. We investigated the effects of repetitive electrical stimulation of the insular cortex (ESI) on mechanical nociception, and general locomotor activity in rats subjected to chronic constriction injury (CCI) of the sciatic nerve. We also studied neuroplastic changes in central pain areas and the involvement of GABAergic signaling on ESI effects. CCI rats had electrodes implanted in the left agranular posterior insular cortex (pIC), and mechanical sensitivity was evaluated before and after one or five daily consecutive ESIs (15 min each, 60 Hz, 210 μs, 1 V). Five ESIs (repetitive ESI) induced sustained mechanical antinociception from the first to the last behavioral assessment without interfering with locomotor activity. A marked increase in Fos immunoreactivity in pIC and a decrease in the anterior and mid-cingulate cortex, periaqueductal gray and hippocampus were noticed after five ESIs. The intrathecal administration of the GABAA receptor antagonist bicuculline methiodide reversed the stimulation-induced antinociception after five ESIs. ESI increased GAD65 levels in pIC but did not interfere with GABA, glutamate or glycine levels. No changes in GFAP immunoreactivity were found in this work. Altogether, the results indicate the efficacy of repetitive ESI for the treatment of experimental neuropathic pain and suggest a potential influence of pIC in regulating pain pathways partially through modulating GABAergic signaling.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent147237pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofBrain Researchpt_BR
dc.titleElectrical stimulation of the posterior insula induces mechanical analgesia in a rodent model of neuropathic pain by modulating GABAergic signaling and activity in the pain circuitrypt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.brainres.2020.147237pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.brainres.2020.147237pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.contributor.externalUniversidade Cidade de São Paulo (UNICID)pt_BR
dc.contributor.externalUniversity of Torontopt_BR
dc.identifier.citationvolume1754pt_BR
dc.subject.keywordInsular cortexpt_BR
dc.subject.keyworddeep brain stimulationpt_BR
dc.subject.keywordchronic painpt_BR
dc.subject.keywordratspt_BR
dc.subject.keywordGABApt_BR
dc.relation.ispartofabbreviatedBrain Res.pt_BR
dc.identifier.citationabntv. 1754, 147237, jan. 2021pt_BR
dc.identifier.citationvancouver2021 Jan;1754:147237pt_BR
dc.contributor.butantanLebrun, Ivo|:Pesquisador:Docente Permamente PPGTOX|:Lab. Bioquímicapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/23522-8pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/25399-4pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/07411-7pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/17136-8pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/18483-1pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦159266/2017-3pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
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