Glutamine supplementation versus functional overload in extensor digitorum longus muscle hypertrophy

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dc.contributor.authorSouza, Diego Ribeiro dept_BR
dc.contributor.authorVasconcelos, Diogo Antonio Alves dept_BR
dc.contributor.authorMurata, Gilson Masahiropt_BR
dc.contributor.authorFortes, Marco Aurélio Salomãopt_BR
dc.contributor.authorMarzuca-Nassr, Gabriel Nasript_BR
dc.contributor.authorLevada-Pires, Adriana Cristinapt_BR
dc.contributor.authorVitzel, Kaio Fernandopt_BR
dc.contributor.authorAbreu, Phablopt_BR
dc.contributor.authorScervino, Maria Vitória Martinspt_BR
dc.contributor.authorHirabara, Sandro Massaopt_BR
dc.contributor.authorCuri, Ruipt_BR
dc.contributor.authorPithon-Curi, Tania Cristinapt_BR
dc.date.accessioned2021-01-15T13:23:37Z-
dc.date.available2021-01-15T13:23:37Z-
dc.date.issued2020pt_BR
dc.identifier.citationSouza DR, Vasconcelos DAA, Murata GM, Fortes MAS, Marzuca-Nassr GN, Levada-Pires AC, et al. Glutamine supplementation versus functional overload in extensor digitorum longus muscle hypertrophy. PharmaNutrition. 2020 Dec;14:100236. doi:10.1016/j.phanu.2020.100236.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3444-
dc.description.abstractBackground Glutamine levels directly associate with total protein content in cultured skeletal muscle cells, whereas glutamine supplementation enhances skeletal muscle mass in catabolic experimental conditions. Methods We compared the effect of glutamine administration on Extensor Digitorum Longus muscle (EDL) weight, fiber cross-sectional area (CSA), contractile activity, and protein metabolism signaling with a functional overload-induced skeletal muscle hypertrophy protocol. Results Glutamine supplementation raised the predominance of EDL muscle fibers with CSA between 1001 and 2000 μm2 (49.7 %), the p-4E-BP1/total 4E-BP1 ratio, and the effect of overload on resistance to fatigue. The proportion of the EDL muscle fiber CSA distribution for the combination of both treatments was similar to that induced by overload or glutamine separately; 54.3 % muscle fibers with CSA between 1001 and 2000 μm². Glutamine supplementation did not markedly affect the changes induced by overload on protein synthesis signaling pathways, except for a further increase of the p-4E-BP1/total 4E-BP1 ratio. Conclusions The effect of glutamine on EDL muscle fiber CSA distribution and protein synthesis signaling mimicked the response to overload. The association of glutamine and overload induced EDL muscle hypertrophy further increased the resistance to fatigue.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.format.extent100236pt_BR
dc.languageengpt_BR
dc.relation.ispartofPharmaNutritionpt_BR
dc.rightsOpen Accesspt_BR
dc.titleGlutamine supplementation versus functional overload in extensor digitorum longus muscle hypertrophypt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.phanu.2020.100236pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.phanu.2020.100236pt_BR
dc.contributor.externalUniversidade Cruzeiro do Sul (UNICSUL)pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.contributor.externalUniversidad de La Fronterapt_BR
dc.contributor.externalUniversidade Federal de Pernambuco (UFPE)pt_BR
dc.contributor.externalEscola de Educação Física da Polícia Militar do Estado de São Paulopt_BR
dc.contributor.externalCentro Universitario Avantis (UniAvan)pt_BR
dc.identifier.citationvolume14pt_BR
dc.subject.keywordAmino acidpt_BR
dc.subject.keywordProtein synthesispt_BR
dc.subject.keywordMuscle fiberpt_BR
dc.subject.keywordEDL musclept_BR
dc.subject.keywordrpS6pt_BR
dc.relation.ispartofabbreviatedPharmaNutritionpt_BR
dc.identifier.citationabntv. 14, 100236, dez, 2020pt_BR
dc.identifier.citationvancouver2020 Dec;14:100236pt_BR
dc.contributor.butantanCuri, Rui|:Diretorpt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.grantfulltextembargo_29990101-
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