Host cell glutamine metabolism as a potential antiviral target

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dc.contributor.authorHirabara, Sandro Massaopt_BR
dc.contributor.authorGorjao, Renatapt_BR
dc.contributor.authorLevada-Pires, Adriana Cristinapt_BR
dc.contributor.authorMasi, Laureane Nunespt_BR
dc.contributor.authorHatanaka, Elainept_BR
dc.contributor.authorCury-Boaventura, Maria Fernandapt_BR
dc.contributor.authorSilva, Eliane Borges dapt_BR
dc.contributor.authorSantos-Oliveira, Laiane Cristina dospt_BR
dc.contributor.authorDiniz, Vinicius Leonardo Sousapt_BR
dc.contributor.authorSerdan, Tamires Afonso Duartept_BR
dc.contributor.authorOliveira, Vivian Araujo Barbosa dept_BR
dc.contributor.authorSouza, Diego Ribeiro dept_BR
dc.contributor.authorGritte, Raquel Bragantept_BR
dc.contributor.authorSouza-Siqueira, Talitapt_BR
dc.contributor.authorZambonatto, Raquel Freitaspt_BR
dc.contributor.authorPithon-Curi, Tania Cristinapt_BR
dc.contributor.authorBazotte, Roberto Barbosapt_BR
dc.contributor.authorNewsholme, Philippt_BR
dc.contributor.authorCuri, Ruipt_BR
dc.date.accessioned2021-01-27T12:29:50Z-
dc.date.available2021-01-27T12:29:50Z-
dc.date.issued2021pt_BR
dc.identifier.citationHirabara SM, Gorjao R, Levada-Pires AC, Masi LN, Hatanaka E, Cury-Boaventura MF, et al. Host cell glutamine metabolism as a potential antiviral target. Clin Sci (Lond). 2021 Jan;135(2):305-325. doi:10.1042/CS20201042.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3481-
dc.description.abstractA virus minimally contains a nucleic acid genome packaged by a protein coat. The genome and capsid together are known as the nucleocapsid, which has an envelope containing a lipid bilayer (mainly phospholipids) originating from host cell membranes. The viral envelope has transmembrane proteins that are usually glycoproteins. The proteins in the envelope bind to host cell receptors, promoting membrane fusion and viral entry into the cell. Virus-infected host cells exhibit marked increases in glutamine utilization and metabolism. Glutamine metabolism generates ATP and precursors for the synthesis of macromolecules to assemble progeny viruses. Some compounds derived from glutamine are used in the synthesis of purines and pyrimidines. These latter compounds are precursors for the synthesis of nucleotides. Inhibitors of glutamine transport and metabolism are potential candidate antiviral drugs. Glutamine is also an essential nutrient for the functions of leukocytes (lymphocyte, macrophage, and neutrophil), including those in virus-infected patients. The increased glutamine requirement for immune cell functions occurs concomitantly with the high glutamine utilization by host cells in virus-infected patients. The development of antiviral drugs that target glutamine metabolism must then be specifically directed at virus-infected host cells to avoid negative effects on immune functions. Therefore, the aim of this review was to describe the landscape of cellular glutamine metabolism to search for potential candidates to inhibit glutamine transport or glutamine metabolism.pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofClinical Sciencept_BR
dc.titleHost cell glutamine metabolism as a potential antiviral targetpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1042/CS20201042pt_BR
dc.identifier.urlhttps://doi.org/10.1042/CS20201042pt_BR
dc.contributor.externalCurtin Universitypt_BR
dc.contributor.externalUniversidade Estadual de Maringá (UEM)pt_BR
dc.contributor.externalUniversidade Cruzeiro do Sul (UNICSUL)pt_BR
dc.identifier.citationvolume135pt_BR
dc.identifier.citationissue2pt_BR
dc.subject.keywordCoronaviruspt_BR
dc.subject.keywordMetabolic Reprogrammingpt_BR
dc.subject.keywordGlutamine Inhibitorspt_BR
dc.subject.keywordGlutaminolysispt_BR
dc.subject.keywordglutamatept_BR
dc.relation.ispartofabbreviatedClin Sci (Lond)pt_BR
dc.identifier.citationabntv. 135, n. 2, p. 305-325, jan. 2021pt_BR
dc.identifier.citationvancouver2021 Jan;135(2):305-325pt_BR
dc.contributor.butantanCuri, Rui|:Diretorpt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextSem Texto completo-
item.grantfulltextnone-
item.languageiso639-1English-
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