Antiangiogenic effects of phospholipase A2 Lys49 BnSP-7 from Bothrops pauloensis snake venom on endothelial cells: An in vitro and ex vivo approach

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dc.contributor.authorPolloni, Lorenapt_BR
dc.contributor.authorAzevedo, Fernanda Van Petten Vasconcelospt_BR
dc.contributor.authorTeixeira, Samuel Cotapt_BR
dc.contributor.authorMoura, Eloápt_BR
dc.contributor.authorCosta, Tassia Rafaelapt_BR
dc.contributor.authorGimenes, Sarah Natalie Cirilopt_BR
dc.contributor.authorCorreia, Lucas Ian Velosopt_BR
dc.contributor.authorFreitas, Vitorpt_BR
dc.contributor.authorYoneyama, Kelly Aparecida Geraldopt_BR
dc.contributor.authorRodrigues, Renata Santospt_BR
dc.contributor.authorLopes, Daiana Silvapt_BR
dc.contributor.authorÁvila, Veridiana de Melo Rodriguespt_BR
dc.date.accessioned2021-01-28T12:38:01Z-
dc.date.available2021-01-28T12:38:01Z-
dc.date.issued2021pt_BR
dc.identifier.citationPolloni L, Azevedo FVPV, Teixeira SC, Moura E, Costa TR, Gimenes SNC, et al. Antiangiogenic effects of phospholipase A2 Lys49 BnSP-7 from Bothrops pauloensis snake venom on endothelial cells: An in vitro and ex vivo approach. Toxicol In Vitro. 2021 Jan;72:105099. doi:10.1016/j.tiv.2021.105099.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3485-
dc.description.abstractAntiangiogenic strategies are promising tools for cancer treatment and several other disorders. In this sense, phospholipases A2 (PLA2s) from snake venom have been described to possess antiangiogenic properties. In this study, we evaluated both in vitro and ex vivo antiangiogenic effects induced by BnSP-7, a Lys49 PLA2 isolated from Bothrops pauloensis snake venom. BnSP-7 was able to inhibit endothelial cell (HUVEC) proliferation, which was indeed confirmed by a modulation of cell cycle progression. Interestingly, BnSP-7 also inhibited the adhesion and migration of HUVECs and blocked in vitro angiogenesis in a VEGF-dependent manner, an important proangiogenic factor. Finally, BnSP-7 was capable of inhibiting sprouting angiogenic process through an ex vivo aortic ring assay. Taken together, these results indicate that BnSP-7 has potent in vitro and ex vivo antiangiogenic effect.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)pt_BR
dc.format.extent105099pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxicology in Vitropt_BR
dc.rightsAcesso restritopt_BR
dc.titleAntiangiogenic effects of phospholipase A2 Lys49 BnSP-7 from Bothrops pauloensis snake venom on endothelial cells: An in vitro and ex vivo approachpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.tiv.2021.105099pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.tiv.2021.105099pt_BR
dc.contributor.externalUniversidade Federal de Uberlândia (UFU)pt_BR
dc.contributor.externalUniversidade Federal da Bahia (UFBA)pt_BR
dc.identifier.citationvolume72pt_BR
dc.subject.keywordPLA2pt_BR
dc.subject.keywordBothrops pauloensispt_BR
dc.subject.keywordAntiangiogenicpt_BR
dc.subject.keywordCancerpt_BR
dc.subject.keywordBnSP-7pt_BR
dc.relation.ispartofabbreviatedToxicol In Vitropt_BR
dc.identifier.citationabntv. 72, 105099, jan. 2021pt_BR
dc.identifier.citationvancouver2021 Jan;72:105099pt_BR
dc.contributor.butantanGimenes, Sarah Natalie Cirilo|:Aluno|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦465669/2014-0pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextembargo_20220501-
item.languageiso639-1English-
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