High intensity interval training control inflammation in mice exposed to Streptococus pneumoniae

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dc.contributorLab. Bacteriologiapt_BR
dc.contributorCentro de Biotecnologiapt_BR
dc.contributor.authorCastro, Thamyres B. P.pt_BR
dc.contributor.authorLaia, Roseane M.pt_BR
dc.contributor.authorMendonça, Luana D.pt_BR
dc.contributor.authorTrindade, Pietro Da Rochapt_BR
dc.contributor.authorSouza, Jessica C.pt_BR
dc.contributor.authorSaraiva-Romanholo Beatriz M.pt_BR
dc.contributor.authorOliveira, Maria Leonor Sarno dept_BR
dc.contributor.authorMiyaji, Eliane Namiept_BR
dc.contributor.authorPrado, Carla M.pt_BR
dc.contributor.authorTiberio, Iolanda F.C.L.pt_BR
dc.contributor.authorOlivo, Clarice Rosapt_BR
dc.date.accessioned2021-02-11T13:22:32Z-
dc.date.available2021-02-11T13:22:32Z-
dc.date.issued2020pt_BR
dc.identifier.citationCastro TB.P., Laia RM., Mendonça LD., Trindade PDR, Souza JC., S-RBM., et al. High intensity interval training control inflammation in mice exposed to Streptococus pneumoniae. Eur Respir J. 2020 56(64):2335. doi:10.1183/13993003.congress-2020.2335.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3518-
dc.description.abstractS.pneumoniae is an important cause of pneumonia. Exercise training is a stimulator of immune system. High Intensity Interval Training (HIIT) have been gain adepts, although their benefits remain unclear. Objective: Evaluate if HIIT prior to S.pneumoniae infection in mice alters lung inflammation. Methods: 38Balb/C mice were divided into 4 groups: Sedentary (SED),HIIT (HIIT), Infection (IF),HIIT+infection (HIIT/IF). HIIT was performed in a treadmill altering 26 session: 1min of 75%¨maximum capacity training and 30s of 50% maximum capacity training, over 4w, 5x/w. 72h after last training, IF groups were challenged with pneumococcal strains M10 (11A)(50 ul/bacteria in saline).Lung function and bronchoalveolar lavage (BAL) were performed 12h after challenge. Afterwards, animals were euthanized, lungs removed to immunohistochemistry and morphometric analysis in lung parenchyma. Results: Pneumococcal inoculation induces an increase in lung resistance (0.74±0.07cmH2O.mL-1.s) and elastance (31.86±8.16 cmH2O.mL-1.s) of respiratory system, in total cells (77.66±54.02x104cells/mL) and neutrophils (73.47±50.88x104cells/mL) in BALF, expression of IL-17 (817.88±217.59mm2) and collagen fibers content in lung parenchyma (17.24±4.54%) (p<0.05). HIIT in inoculated animals resulted in a reduction of all parameters (p<0.05), except for lung resistance. HIIT groups presented increasing expression of IL-1ra (698.64±432.42mm2), CuZnSOD (576.42±138.18mm2), IL-33 (990.07±212.47mm2)(p<0.001). Conclusion: HIIT attenuated inflammatory process induced by S.pneumoniae, increasing antiinflammatory mediators and antioxidant enzymes, reducing proinflammatory mediators.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipUniversidade de São Paulo (USP)pt_BR
dc.format.extent2335pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofThe European Respiratory Journalpt_BR
dc.titleHigh intensity interval training control inflammation in mice exposed to Streptococus pneumoniaept_BR
dc.typeArticlept_BR
dc.identifier.doi10.1183/13993003.congress-2020.2335pt_BR
dc.identifier.urlhttps://doi.org/10.1183/13993003.congress-2020.2335pt_BR
dc.contributor.externalUniversidade Cidade de São Paulo (UNICID)pt_BR
dc.contributor.externalInstituto de Assistência Médica ao Servidor Público Estadual de S. Paulo (IAMSPE)pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.contributor.externalUniversidade Federal de São Paulo (UNIFESP)pt_BR
dc.identifier.citationvolume56pt_BR
dc.identifier.citationissue64pt_BR
dc.relation.ispartofabbreviatedEur Respir Jpt_BR
dc.identifier.citationabntv. 56, n. 64, 2335, 2020pt_BR
dc.identifier.citationvancouver2020 56(64):2335pt_BR
dc.contributor.butantanOliveira, Maria Leonor Sarno de|:Pesquisador|:Centro de Biotecnologia|:Lab. Bacteriologiapt_BR
dc.contributor.butantanMiyaji, Eliane Namie|:Pesquisador|:Centro de Biotecnologia|:Lab. Bacteriologiapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦19966-6pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦pt_BR
dc.sponsorship.butantanUniversidade de São Paulo (USP)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.grantfulltextnone-
item.languageiso639-1English-
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