Serum levels of anti-PspA and anti-PspC IgG decrease with age and do not correlate with susceptibility to experimental human pneumococcal colonization

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dc.contributorLab. Bacteriologiapt_BR
dc.contributor.authorAdriano Palharini de Araujopt_BR
dc.contributor.authorColichio, Gabriela Borges Cherullipt_BR
dc.contributor.authorOliveira, Maria Leonor Sarno dept_BR
dc.contributor.authorGerman, Estherpt_BR
dc.contributor.authorNikolaou, Elissavetpt_BR
dc.contributor.authorChen, Taopt_BR
dc.contributor.authorAdler, Hughpt_BR
dc.contributor.authorFerreira, Daniela M.pt_BR
dc.contributor.authorMiyaji, Eliane Namiept_BR
dc.date.accessioned2021-02-18T12:09:59Z-
dc.date.available2021-02-18T12:09:59Z-
dc.date.issued2021pt_BR
dc.identifier.citationAPA, Colichio GBC, Oliveira MLS, German E, Nikolaou E, Chen T, et al. Serum levels of anti-PspA and anti-PspC IgG decrease with age and do not correlate with susceptibility to experimental human pneumococcal colonization. PloS One. 2021 Fev;16(2)e0246540. doi:10.1371/journal.pone.0247056.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3539-
dc.description.abstractOlder adults are at increased risk of pneumococcal disease. This work aims to evaluate whether there is any decrease in serum IgG against variants of the antigens Pneumococcal surface protein A (PspA) and Pneumococcal surface protein C (PspC) in healthy adults with increasing age. Levels of IgG against PspA and PspC variants were determined by ELISA in serum samples comparing volunteers 18–30 years of age with volunteers who were 50–70+ before and after an experimental pneumococcal colonization challenge. The serotype 6B strain used in the challenge belongs to a minor group of pneumococcal isolates expressing two PspC variants. There was a decrease in levels of IgG with increasing age for the most common PspA variants and for all PspC variants analyzed. No correlation was found between basal levels of IgG against these antigens and protection against colonization. There was an increase in levels of IgG against PspA variants that are more cross-reactive with the variant expressed by the challenge strain post challenge in younger individuals who became colonized. Since the challenge strain used in our study expresses two different PspC variants, an increase in serum IgG against all PspC variants tested was observed in younger individuals who became colonized. For some of the antigen variants tested, a decrease in serum IgG was observed in young volunteers who were challenged but did not become colonized. Serum IgG antibodies against PspA and PspC variants thus decrease with age in healthy adults, but there is no correlation between levels of IgG against these antigens and protection against human experimental colonization. Though no correlation between naturally induced serum IgG antibodies against PspA and PspC and protection against colonization was observed, these results do not rule out the protective potential of these antigens as vaccines against pneumococcal infections.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação Butantanpt_BR
dc.description.sponsorshipBill & Melinda Gates Foundationpt_BR
dc.description.sponsorshipMedical Research Council (MRC)pt_BR
dc.format.extente0247056pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofPloS Onept_BR
dc.rightsOpen Accesspt_BR
dc.titleSerum levels of anti-PspA and anti-PspC IgG decrease with age and do not correlate with susceptibility to experimental human pneumococcal colonizationpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1371/journal.pone.0247056pt_BR
dc.identifier.urlhttps://doi.org/10.1371/journal.pone.0247056pt_BR
dc.contributor.externalLiverpool School of Tropical Medicine (LSTM)pt_BR
dc.identifier.citationvolume16pt_BR
dc.identifier.citationissue2pt_BR
dc.relation.ispartofabbreviatedPloS Onept_BR
dc.identifier.citationabntv. 16, n. 2, e0246540, fev. 2021pt_BR
dc.identifier.citationvancouver2021 Fev;16(2)e0246540pt_BR
dc.contributor.butantanAdriano Palharini de Araujo:Aluno|:Lab. Bacteriologiapt_BR
dc.contributor.butantanColichio, Gabriela Borges Cherulli|:Aluno|:Lab. Bacteriologiapt_BR
dc.contributor.butantanOliveira, Maria Leonor Sarno de|:Pesquisador|:Lab. Bacteriologiapt_BR
dc.contributor.butantanMiyaji, Eliane Namie|:Pesquisador|:Lab. Bacteriologia|:Autor de correspondênciapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/ 25165-6pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦303072/2018-0pt_BR
dc.sponsorship.butantanFundação Butantan¦¦pt_BR
dc.sponsorship.butantanBill & Melinda Gates Foundation¦¦OPP1117728pt_BR
dc.sponsorship.butantanMedical Research Council (MRC)¦¦MR/M011569/1pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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item.languageiso639-1English-
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