Profiling plasma-extracellular vesicle proteins and microRNAs in diabetes onset in middle-aged male participants in the ELSA-Brasil study

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dc.contributorDiretoria Técnicapt_BR
dc.contributor.authorMasi, Laureane N.pt_BR
dc.contributor.authorLotufo, Paulo A.pt_BR
dc.contributor.authorFerreira, Frederico M.pt_BR
dc.contributor.authorRodrigues, Alice C.pt_BR
dc.contributor.authorSerdan, Tamires D. A.pt_BR
dc.contributor.authorSouza‐Siqueira, Talitapt_BR
dc.contributor.authorBraga, Aécio A.pt_BR
dc.contributor.authorSaldarriaga, Magda E. G.pt_BR
dc.contributor.authorAlba‐Loureiro, Tatiana C.pt_BR
dc.contributor.authorBorges, Fernanda T.pt_BR
dc.contributor.authorCury, Diego P.pt_BR
dc.contributor.authorHirata, Mario H.pt_BR
dc.contributor.authorGorjão, Renatapt_BR
dc.contributor.authorPithon‐Curi, Tania C.pt_BR
dc.contributor.authorLottenberg, Simão A.pt_BR
dc.contributor.authorFedeli, Ligia M. G.pt_BR
dc.contributor.authorNakaya, Helder T. I.pt_BR
dc.contributor.authorBensenor, Isabela J. M.pt_BR
dc.contributor.authorCuri, Ruipt_BR
dc.contributor.authorHirabara, Sandro M.pt_BR
dc.date.accessioned2021-02-23T11:52:22Z-
dc.date.available2021-02-23T11:52:22Z-
dc.date.issued2021pt_BR
dc.identifier.citationMasi LN., Lotufo PA., Ferreira FM., Rodrigues AC., Serdan TD.A., Souza‐Siqueira T, et al. Profiling plasma-extracellular vesicle proteins and microRNAs in diabetes onset in middle-aged male participants in the ELSA-Brasil study. Physiol. Rep.. 2021 Fev;9(3):e14731. doi:10.14814/phy2.14731.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3562-
dc.description.abstractWe measured plasma‐derived extracellular vesicle (EV) proteins and their microRNA (miRNA) cargos in normoglycemic (NG), glucose intolerant (GI), and newly diagnosed diabetes mellitus (DM) in middle‐aged male participants of the Brazilian Longitudinal Study of Adult Health (ELSA‐Brazil). Mass spectrometry revealed decreased IGHG‐1 and increased ITIH2 protein levels in the GI group compared with that in the NG group and higher serotransferrin in EVs in the DM group than in those in the NG and GI groups. The GI group also showed increased serum ferritin levels, as evaluated by biochemical analysis, compared with those in both groups. Seventeen miRNAs were differentially expressed (DEMiRs) in the plasma EVs of the three groups. DM patients showed upregulation of miR‐141‐3p and downregulation of miR‐324‐5p and ‐376c‐3p compared with the NG and GI groups. The DM and GI groups showed increased miR‐26b‐5p expression compared with that in the NG group. The DM group showed decreased miR‐374b‐5p levels compared with those in the GI group and higher concentrations than those in the NG group. Thus, three EV proteins and five DEMiR cargos have potential prognostic importance for diabetic complications mainly associated with the immune function and iron status of GI and DM patients.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipUniversidade Cruzeiro do Sul (UNICSUL)pt_BR
dc.description.sponsorshipMinistério da Ciência, Tecnologia e Inovaçõespt_BR
dc.format.extente14731pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofPhysiological Reportspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleProfiling plasma-extracellular vesicle proteins and microRNAs in diabetes onset in middle-aged male participants in the ELSA-Brasil studypt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.14814/phy2.14731pt_BR
dc.identifier.urlhttps://doi.org/10.14814/phy2.14731pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.external(UNICSUL) Universidade Cruzeiro do Sulpt_BR
dc.identifier.citationvolume9pt_BR
dc.identifier.citationissue3pt_BR
dc.subject.keywordepigeneticspt_BR
dc.subject.keywordglucose intolerancept_BR
dc.subject.keywordhyperglycemiapt_BR
dc.subject.keywordproteomicpt_BR
dc.relation.ispartofabbreviatedPhysiol Reppt_BR
dc.identifier.citationabntv. 9, n. 3, e14731, fev. 2021pt_BR
dc.identifier.citationvancouver2021 Fev;9(3):e14731pt_BR
dc.contributor.butantanCuri, Rui|:Outros|:Diretoria Técnicapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2014/21447‐6pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2015/12728‐4pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/03707‐9pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/00998‐5pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/25892‐8pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦457358/2013‐0pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦303574/2015‐1pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦312018/2018‐5pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦88881.068515/2014‐01pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦88881.170862/2018‐01pt_BR
dc.sponsorship.butantanUniversidade Cruzeiro do Sul (UNICSUL)¦¦0708/2018pt_BR
dc.sponsorship.butantanMinistério da Ciência, Tecnologia e Inovações¦¦01 06 0010.00 RSpt_BR
dc.sponsorship.butantanMinistério da Ciência, Tecnologia e Inovações¦¦01 06 0212.00 BApt_BR
dc.sponsorship.butantanMinistério da Ciência, Tecnologia e Inovações¦¦01 06 0300.00 ESpt_BR
dc.sponsorship.butantanMinistério da Ciência, Tecnologia e Inovações¦¦0106 0278.00 MGpt_BR
dc.sponsorship.butantanMinistério da Ciência, Tecnologia e Inovações¦¦01 06 0115.00 SPpt_BR
dc.sponsorship.butantanMinistério da Ciência, Tecnologia e Inovações¦¦01 06 0071.00 RJpt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
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