BCG vaccination improves DTaP immune responses in mice and is associated with lower pertussis incidence in ecological epidemiological studies

Full metadata record
DC FieldValueLanguage
dc.contributorLaboratório de Desenvolvimento de Vacinaspt_BR
dc.contributor.authorBroset, Estherpt_BR
dc.contributor.authorPardo-Seco, Jacobopt_BR
dc.contributor.authorKanno, Alex Issamupt_BR
dc.contributor.authorAguilo, Nachopt_BR
dc.contributor.authorDacosta, Ana Isabelpt_BR
dc.contributor.authorRivero-Calle, Irenept_BR
dc.contributor.authorGonzalo-Asensio, Jesuspt_BR
dc.contributor.authorLocht, Camillept_BR
dc.contributor.authorLeite, Luciana Cezar de Cerqueirapt_BR
dc.contributor.authorMartin, Carlospt_BR
dc.contributor.authorMartinón-Torres, Federicopt_BR
dc.date.accessioned2021-03-18T17:07:29Z-
dc.date.available2021-03-18T17:07:29Z-
dc.date.issued2021pt_BR
dc.identifier.citationBroset E, Pardo-Seco J, Kanno AI, Aguilo N, Dacosta AI, Rivero-Calle I, et al. BCG vaccination improves DTaP immune responses in mice and is associated with lower pertussis incidence in ecological epidemiological studies. EBioMedicine. 2021 Mar;65:103254. doi:10.1016/j.ebiom.2021.103254.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3630-
dc.description.abstractBackground: The Bacillus Calmette-Guérin (BCG), the only vaccine against tuberculosis (TB) currently in use, has shown beneficial effects against unrelated infections and to enhance immune responses to vaccines. However, there is little evidence regarding the influence of BCG vaccination on pertussis. Methods: Here, we studied the ability of BCG to improve the immune responses to diphtheria, tetanus, and acellular (DTaP) or whole-cell pertussis (DTwP) vaccination in a mouse model. We included MTBVAC, an experimental live-attenuated vaccine derived from Mycobacterium tuberculosis, in our studies to explore if it presents similar heterologous immunity as BCG. Furthermore, we explored the potential effect of routine BCG vaccination on pertussis incidence worldwide. Findings: We found that both BCG and MTBVAC when administered before DTaP, triggered Th1 immune responses against diphtheria, tetanus, and pertussis in mice. Immunization with DTaP alone failed to trigger a Th1 response, as measured by the production of IFN-γ. Humoral responses against DTaP antigens were also enhanced by previous immunization with BCG or MTBVAC. Furthermore, exploration of human epidemiological data showed that pertussis incidence was 10-fold lower in countries that use DTaP and BCG compared to countries that use only DTaP. Interpretation: BCG vaccination may have a beneficial impact on the protection against pertussis conferred by DTaP. Further randomized controlled trials are needed to properly define the impact of BCG on pertussis incidence in a controlled setting. This could be a major finding that would support changes in immunization policies.pt_BR
dc.description.sponsorshipInstituto de Salud Carlos IIIpt_BR
dc.description.sponsorshipFondo de Investigacion Sanitaria (FIS)pt_BR
dc.description.sponsorshipMinisterio de Economía y Competitividadpt_BR
dc.description.sponsorshipEuropean Commission (EC)pt_BR
dc.format.extent103254pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofEBioMedicinept_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/pt_BR
dc.titleBCG vaccination improves DTaP immune responses in mice and is associated with lower pertussis incidence in ecological epidemiological studiespt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BY-NC-NDpt_BR
dc.identifier.doi10.1016/j.ebiom.2021.103254pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.ebiom.2021.103254pt_BR
dc.contributor.externalUniversidad de Zaragozapt_BR
dc.contributor.externalCarlos III Health Institutept_BR
dc.contributor.externalUniversity of Santiago de Compostelapt_BR
dc.contributor.externalHospital Clínico Universitario de Santiagopt_BR
dc.contributor.externalInstitut Pasteur de Lillept_BR
dc.contributor.externalHospital Universitario Miguel Servetpt_BR
dc.contributor.externalUniversidad de Lillept_BR
dc.contributor.externalInstituto de Biocomputacion y Física de Sistemas Complejos (BIFI)pt_BR
dc.identifier.citationvolume65pt_BR
dc.subject.keywordLive-tuberculosis vaccinespt_BR
dc.subject.keywordHeterologous immunitypt_BR
dc.subject.keywordNon-specific effectspt_BR
dc.subject.keywordDTPpt_BR
dc.subject.keywordBCGpt_BR
dc.subject.keywordMTBVACpt_BR
dc.relation.ispartofabbreviatedEBioMedicinept_BR
dc.identifier.citationabntv. 65, 103254, mar. 2021pt_BR
dc.identifier.citationvancouver2021 Mar;65:103254pt_BR
dc.contributor.butantanKanno, Alex Issamu|:Aluno|:Laboratório de Desenvolvimento de Vacinaspt_BR
dc.contributor.butantanLeite, Luciana Cezar de Cerqueira|:Pesquisador|:Laboratório de Desenvolvimento de Vacinaspt_BR
dc.sponsorship.butantanInstituto de Salud Carlos III¦¦ISCIII/PI16/01478pt_BR
dc.sponsorship.butantanInstituto de Salud Carlos III¦¦ISCIII/PI16/01569pt_BR
dc.sponsorship.butantanInstituto de Salud Carlos III¦¦RHI07/2pt_BR
dc.sponsorship.butantanInstituto de Salud Carlos III¦¦PS09749pt_BR
dc.sponsorship.butantanInstituto de Salud Carlos III¦¦10PXIB918184PRpt_BR
dc.sponsorship.butantanInstituto de Salud Carlos III¦¦PI16/01569pt_BR
dc.sponsorship.butantanFondo de Investigacion Sanitaria (FIS)¦¦PI070069pt_BR
dc.sponsorship.butantanFondo de Investigacion Sanitaria (FIS)¦¦PI1000540pt_BR
dc.sponsorship.butantanFondo de Investigacion Sanitaria (FIS)¦¦PI1901090pt_BR
dc.sponsorship.butantanMinisterio de Economía y Competitividad¦¦BFU2015-72190-EXPpt_BR
dc.sponsorship.butantanMinisterio de Economía y Competitividad¦¦BES-2012- 052937pt_BR
dc.sponsorship.butantanMinisterio de Economía y Competitividad¦¦RTI2018-097625-B-I00pt_BR
dc.sponsorship.butantanEuropean Commission (EC)¦¦)RIA2016V-1637pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
item.fulltextCom Texto completo-
item.openairetypeArticle-
item.grantfulltextopen-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid0000-0003-0156-1312-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journalissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journaleissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
Appears in Collections:Artigos de periódicos


Files in This Item:

10.1016j.ebiom.2021.103254.pdf
Description:
Size: 2 MB
Format: Adobe PDF
View/Open
Show simple item record

This item is licensed under a Creative Commons License Creative Commons