Monosodium glutamate administration early in life alters pineal melatonin nocturnal profile in adulthood

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dc.contributorLab. Farmacologiapt_BR
dc.contributor.authorGarcia, Janaína Bpt_BR
dc.contributor.authorAmaral, Fernanda G dopt_BR
dc.contributor.authorBuonfiglio, Daniela Cpt_BR
dc.contributor.authorVendrame, Rafaela FApt_BR
dc.contributor.authorAlves, Patrícia Lúciopt_BR
dc.contributor.authorPaulo, Maria Eliza Ferreira do Val dept_BR
dc.contributor.authorScialfa, Julieta Hpt_BR
dc.contributor.authorSilveira, Paulo Fláviopt_BR
dc.contributor.authorCipolla-Neto, Josépt_BR
dc.contributor.authorAfeche, Solange Castropt_BR
dc.identifier.citationGarcia JB, Amaral FG, Buonfiglio DC, Vendrame RFA, Alves PL, Paulo MEFV, et al. Monosodium glutamate administration early in life alters pineal melatonin nocturnal profile in adulthood. Melatonin Research. 2021 Jan;4(1):99-114. doi:10.32794/mr11250084.pt_BR
dc.description.abstractThe pinealgland synthesizes melatonin exclusively at night, which gives melatonin the characteristic of a temporal synchronizer of the physiological systems. Melatonin is a regulator of insulin activities centrally and also peripherally and its synthesis is reduced in diabetes. Since monosodium glutamate (MSG) is often used to induce the type 2 diabetic and metabolic syndrome in animal models, the purpose of this work is to evaluate the potential effects of MSG given to neonates on the pineal melatonin synthesis in different agedmale and female rats. Wistar rats were subcutaneously injected with MSG (4mg/g/day) or saline solution (0.9%) from the second to eighth post-natal day. The circadian profiles both melatonin levels and AANAT activity were monitored at different ages. Body weight, naso-anal length, adipose tissues weight, GTT, ITT and serum insulin levels were also evaluated. Typical obesity with the neonatal MSG treatment was observed, indicated by a great increase in adipose depots without a concurrent increase in body weight. MSG treatment did not cause hyperglycemia or glucose intolerance, but induced insulin resistance. An increase of melatonin synthesis at ZT 15 with phase advance was observed in in some animals. The AANAT activity was positively parallel to the melatonin circadian profile. It seems that MSG causes hypothalamic obesity which may increase AANAT activity and melatonin production in pineal gland. These effects were not temporally correlated with insulin resistance and hyperinsulinemia indicating the hypothalamic lesions, particularly in arcuate nucleus induced by MSG in early age, as the principal cause of the increase in melatonin production.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.relation.ispartofMelatonin Researchpt_BR
dc.rightsOpen Accesspt_BR
dc.titleMonosodium glutamate administration early in life alters pineal melatonin nocturnal profile in adulthoodpt_BR
dc.contributor.externalUniversidade Federal de São Paulo (UNIFESP)pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.contributor.externalUniversidade do Oeste Paulista (UNOESTE)pt_BR
dc.subject.keywordMonosodium glutamatept_BR
dc.subject.keywordpineal glandpt_BR
dc.subject.keywordhypothalamic obesitypt_BR
dc.subject.keywordinsulin resistancept_BR
dc.relation.ispartofabbreviatedMelatonin Researchpt_BR
dc.identifier.citationabntv. 4, n. 1, p. 99-114, jan. 2021pt_BR
dc.identifier.citationvancouver2021 Jan;4(1):99-114pt_BR
dc.contributor.butantanGarcia, Janaína B|: |:Lab. Farmacologia|:PrimeiroAutorpt_BR
dc.contributor.butantanAlves, Patrícia Lúcio|:Aluno |:Lab. Farmacologiapt_BR
dc.contributor.butantanPaulo, Maria Eliza Ferreira do Val de|:Técnico|:Lab. Farmacologiapt_BR
dc.contributor.butantanSilveira, Paulo Flávio|:Pesquisador|:Lab. Farmacologiapt_BR
dc.contributor.butantanAfeche, Solange Castro|:Pesquisador|:Lab. Farmacologiapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/50457-0pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦pt_BR
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