The prospective use of Brazilian marine macroalgae in Schistosomiasis control

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dc.contributorLab. Parasitologiapt_BR
dc.contributor.authorStein, Erika M.pt_BR
dc.contributor.authorTajú, Sara Guibundapt_BR
dc.contributor.authorMiyasato, Patricia Aokipt_BR
dc.contributor.authorFreitas, Rafaela Paula dept_BR
dc.contributor.authorTallarico, Lenita de Freitaspt_BR
dc.contributor.authorSantos, Guilherme S. dospt_BR
dc.contributor.authorLuiz, Giovana Leite Ferreirapt_BR
dc.contributor.authorRofatto, Henrique Krambeckpt_BR
dc.contributor.authorSilva, Fábio N. V. dapt_BR
dc.contributor.authorColepicolo, Piopt_BR
dc.contributor.authorMacedo, Arthur L.pt_BR
dc.contributor.authorCarollo, Carlos A.pt_BR
dc.contributor.authorNakano, Elianapt_BR
dc.identifier.citationStein EM., Tajú SG, Miyasato PA, Freitas RP, Tallarico LF, Santos GS., et al. The prospective use of Brazilian marine macroalgae in Schistosomiasis control. Marine Drugs. 2021 Apr;19(5):234. doi:10.3390/md19050234.pt_BR
dc.description.abstractSchistosomiasis is a parasitic disease that affects more than 250 million people. The treatment is limited to praziquantel and the control of the intermediate host with the highly toxic molluscicidal niclosamide. Marine algae are a poorly explored and promising alternative that can provide lead compounds, and the use of multivariate analysis could contribute to quicker discovery. As part of our search for new natural compounds with which to control schistosomiasis, we screened 45 crude extracts obtained from 37 Brazilian seaweed species for their molluscicidal activity against Biomphalaria glabrata embryos and schistosomicidal activities against Schistosoma mansoni. Two sets of extracts were taxonomically grouped for metabolomic analysis. The extracts were analyzed by GC–MS, and the data were subjected to Pattern Hunter and Pearson correlation tests. Overall, 22 species (60%) showed activity in at least one of the two models. Multivariate analysis pointed towards 3 hits against B. glabrata veliger embryos in the Laurencia/Laurenciella set, 5 hits against B. glabrata blastula embryos, and 31 against S. mansoni in the Ochrophyta set. Preliminary annotations suggested some compounds such as triquinane alcohols, prenylated guaianes, dichotomanes, and xenianes. Despite the putative identification, this work presents potential candidates and can guide future isolation and identificationpt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.relation.ispartofMarine Drugspt_BR
dc.rightsOpen Accesspt_BR
dc.titleThe prospective use of Brazilian marine macroalgae in Schistosomiasis controlpt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.contributor.externalUniversidade Federal de Mato Grosso do Sul (UFMS)pt_BR
dc.subject.keywordmetabolomic analysispt_BR
dc.subject.keywordPattern Hunter testpt_BR
dc.subject.keywordPearson correlation testpt_BR
dc.relation.ispartofabbreviatedMarine Drugspt_BR
dc.identifier.citationabntv. 19, n. 5, 234, abr. 2021pt_BR
dc.identifier.citationvancouver2021 Apr;19(5):234pt_BR
dc.contributor.butantanTajú, Sara Guibunda|:Aluno|:Lab. Parasitologiapt_BR
dc.contributor.butantanMiyasato, Patricia Aoki|:Técnico|:Lab. Parasitologiapt_BR
dc.contributor.butantanRafaela Paula de Freitas|:Técnico|:Lab. Parasitologiapt_BR
dc.contributor.butantanTallarico, Lenita de Freitas|:Aluno|:Lab. Parasitologiapt_BR
dc.contributor.butantanGuilherme S. dos Santos|:Aluno|:Lab. Parasitologiapt_BR
dc.contributor.butantanLuiz, Giovana Leite Ferreira|:Aluno|:Lab. Parasitologiapt_BR
dc.contributor.butantanRofatto, Henrique Krambeck|:Aluno|:Lab. Parasitologiapt_BR
dc.contributor.butantanNakano, Eliana|:Pesquisador|:Lab. Parasitologia|:Autor de correspondênciapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/16223-7pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/06931-4pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/07346-0pt_BR
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