Hybrid atypical enteropathogenic and extraintestinal Escherichia coli (aEPEC/ExPEC) BA1250 strain: a draft genome

Full metadata record
DC FieldValueLanguage
dc.contributorLab. Bacteriologiapt_BR
dc.contributor.authorMunhoz, Danielle Diaspt_BR
dc.contributor.authorSantos, Fernanda F.pt_BR
dc.contributor.authorMitsunari, Thaíspt_BR
dc.contributor.authorSchüroff, Paulo Alfonsopt_BR
dc.contributor.authorElias, Waldir Pereirapt_BR
dc.contributor.authorCarvalho, Eneaspt_BR
dc.contributor.authorPiazza, Roxane Maria Fontespt_BR
dc.date.accessioned2021-05-04T18:50:02Z-
dc.date.available2021-05-04T18:50:02Z-
dc.date.issued2021pt_BR
dc.identifier.citationMunhoz DD, Santos FF., Mitsunari T, Schüroff PA, Elias WP, Carvalho E, et al. Hybrid atypical enteropathogenic and extraintestinal Escherichia coli (aEPEC/ExPEC) BA1250 strain: a draft genome. Pathogens. 2021 Apr;10(4):475. doi:10.3390/pathogens10040475.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3694-
dc.description.abstractDiarrheagenic Escherichia coli is the major bacterial etiological agent of severe diarrhea and a major concern of public health. These pathogens have acquired genetic characteristics from other pathotypes, leading to unusual and singular genetic combinations, known as hybrid strains and may be more virulent due to a set of virulence factors from more than one pathotype. One of the possible combinations is with extraintestinal E. coli (ExPEC), a leading cause of urinary tract infection, often lethal after entering the bloodstream and atypical enteropathogenic E. coli (aEPEC), responsible for death of thousands of people every year, mainly children under five years old. Here we report the draft genome of a strain originally classified as aEPEC (BA1250) isolated from feces of a child with acute diarrhea. Phylogenetic analysis indicates that BA1250 genome content is genetically closer to E. coli strains that cause extraintestinal infections, other than intestinal infections. A deeper analysis showed that in fact this is a hybrid strain, due to the presence of a set of genes typically characteristic of ExPEC. These genomic findings expand our knowledge about aEPEC heterogeneity allowing further studies concerning E. coli pathogenicity and may be a source for future comparative studies, virulence characteristics, and evolutionary biology.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent475pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofPathogenspt_BR
dc.rightsOpen Accesspt_BR
dc.titleHybrid atypical enteropathogenic and extraintestinal Escherichia coli (aEPEC/ExPEC) BA1250 strain: a draft genomept_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/pathogens10040475pt_BR
dc.identifier.urlhttps://doi.org/10.3390/pathogens10040475pt_BR
dc.contributor.externalUniversidade Federal de São Paulo (UNIFESP)pt_BR
dc.identifier.citationvolume10pt_BR
dc.identifier.citationissue4pt_BR
dc.subject.keywordE. colipt_BR
dc.subject.keyworddiarrheapt_BR
dc.subject.keywordaEPECpt_BR
dc.subject.keywordgenome evolutionpt_BR
dc.subject.keywordextraintestinal pathogenpt_BR
dc.relation.ispartofabbreviatedPathogenspt_BR
dc.identifier.citationabntv. 10, n. 4, 475, abr. 2021pt_BR
dc.identifier.citationvancouver2021 Apr;10(4):475pt_BR
dc.contributor.butantanMunhoz, Danielle Dias|:Aluno|:Lab. Bacteriologia|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanMitsunari, Thaís|:Aluno|:Lab. Bacteriologiapt_BR
dc.contributor.butantanSchüroff, Paulo Alfonso|:Aluno|:Lab. Bacteriologiapt_BR
dc.contributor.butantanElias, Waldir Pereira|:Pesquisador|:Lab. Bacteriologiapt_BR
dc.contributor.butantanCarvalho, Eneas|:Pesquisador|:Lab. Bacteriologiapt_BR
dc.contributor.butantanPiazza, Roxane Maria Fontes|:Pesquisador:Docente Permanente PPGTOX|:Lab. Bacteriologia|:Autor de correspondênciapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/06610-9pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/25406-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/14821-7pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦140088/2016-4pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.grantfulltextopen-
item.languageiso639-1English-
item.openairetypeArticle-
item.fulltextCom Texto completo-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid0000-0003-3470-5706-
crisitem.author.orcid0000-0002-8052-0975-
crisitem.author.orcid0000-0003-0068-8506-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journalissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journaleissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
Appears in Collections:Artigos de periódicos


Files in This Item:

10.3390pathogens10040475.pdf
Description:
Size: 2.52 MB
Format: Adobe PDF
View/Open
Show simple item record

The access to the publications deposited in this repository respects the licenses from journals and publishers.