Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory

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dc.contributorLEDV - Laboratório de Desenvolvimento de Vacinaspt_BR
dc.contributor.authorBarbosa, Mayra Mara Ferraript_BR
dc.contributor.authorKanno, Alex Issamupt_BR
dc.contributor.authorFarias, Leonardo Paivapt_BR
dc.contributor.authorMadej, Mariuszpt_BR
dc.contributor.authorSipos, Gergöpt_BR
dc.contributor.authorSbrana, Silveriopt_BR
dc.contributor.authorRomani, Luiginapt_BR
dc.contributor.authorBoraschi, Dianapt_BR
dc.contributor.authorLeite, Luciana Cezar de Cerqueirapt_BR
dc.contributor.authorItaliani, Paolapt_BR
dc.date.accessioned2021-05-04T19:36:52Z-
dc.date.available2021-05-04T19:36:52Z-
dc.date.issued2021pt_BR
dc.identifier.citationBarbosa MMF, Kanno AI, Farias LP, Madej M, Sipos G, Sbrana S, et al. Primary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memory. Nanomaterials. 2021 Apr;11(4):931. doi:10.3390/nano11040931.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3695-
dc.description.abstractInnate immune cells such as monocytes and macrophages are activated in response to microbial and other challenges and mount an inflammatory defensive response. Exposed cells develop the so-called innate memory, which allows them to react differently to a subsequent challenge, aiming at better protection. In this study, using human primary monocytes in vitro, we have assessed the memory-inducing capacity of two antigenic molecules of Schistosoma mansoni in soluble form compared to the same molecules coupled to outer membrane vesicles of Neisseria lactamica. The results show that particulate challenges are much more efficient than soluble molecules in inducing innate memory, which is measured as the production of inflammatory and anti-inflammatory cytokines (TNFα, IL-6, IL-10). Controls run with LPS from Klebsiella pneumoniae compared to the whole bacteria show that while LPS alone has strong memory-inducing capacity, the entire bacteria are more efficient. These data suggest that microbial antigens that are unable to induce innate immune activation can nevertheless participate in innate activation and memory when in a particulate form, which is a notion that supports the use of nanoparticulate antigens in vaccination strategies for achieving adjuvant-like effects of innate activation as well as priming for improved reactivity to future challenges.pt_BR
dc.description.sponsorshipEuropean Commission (EC)pt_BR
dc.description.sponsorshipMIUR-PRINpt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipFundação Butantanpt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.format.extent931pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofNanomaterialspt_BR
dc.rightsOpen Accesspt_BR
dc.titlePrimary and memory response of human monocytes to vaccines: role of nanoparticulate antigens in inducing innate memorypt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/nano11040931pt_BR
dc.identifier.urlhttps://doi.org/10.3390/nano11040931pt_BR
dc.contributor.externalFundação Oswaldo Cruz (Fiocruz)pt_BR
dc.contributor.externalConsiglio Nazionale delle Ricerchept_BR
dc.contributor.externalUniversity of Perugiapt_BR
dc.contributor.externalStazione Zoologica Anton Dohrnpt_BR
dc.identifier.citationvolume11pt_BR
dc.identifier.citationissue4pt_BR
dc.subject.keywordinnate immunitypt_BR
dc.subject.keywordinnate memorypt_BR
dc.subject.keywordSchistosoma mansonipt_BR
dc.subject.keywordmonocytespt_BR
dc.subject.keywordmacrophagespt_BR
dc.subject.keywordvaccinationpt_BR
dc.relation.ispartofabbreviatedNanomaterialspt_BR
dc.identifier.citationabntv. 11, n. 4, 931, abr. 2021pt_BR
dc.identifier.citationvancouver2021 Apr;11(4):931pt_BR
dc.contributor.butantanBarbosa, Mayra Mara Ferrari|:Aluno|:LEDV - Laboratório de Desenvolvimento de Vacinas|:PrimeiroAutorpt_BR
dc.contributor.butantanKanno, Alex Issamu|:Aluno|:LEDV - Laboratório de Desenvolvimento de Vacinaspt_BR
dc.contributor.butantanLeite, Luciana Cezar de Cerqueira|:Pesquisador|:LEDV - Laboratório de Desenvolvimento de Vacinas|:Autor de correspondênciapt_BR
dc.sponsorship.butantanEuropean Commission (EC)¦¦316383pt_BR
dc.sponsorship.butantanEuropean Commission (EC)¦¦671881pt_BR
dc.sponsorship.butantanEuropean Commission (EC)¦¦812661pt_BR
dc.sponsorship.butantanMIUR-PRIN¦¦20173ZECCMpt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/24632-6pt_BR
dc.sponsorship.butantanFundação Butantan¦¦pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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