Neurotoxicity of Olindias sambaquiensis and Chiropsalmus quadrumanus extracts in sympathetic nervous system

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dc.contributorLEDS - Laboratório de Dor e Sinalizaçãopt_BR
dc.contributor.authorBueno, Thais Cavenattipt_BR
dc.contributor.authorCollaço, Rita de Cássiapt_BR
dc.contributor.authorCardoso, Bianca Aparecidapt_BR
dc.contributor.authorBredariol, Rafael Fumachipt_BR
dc.contributor.authorEscobar, Marília Lealpt_BR
dc.contributor.authorCajado, Isabela Bubenikpt_BR
dc.contributor.authorGracia, Martapt_BR
dc.contributor.authorAntunes, Edsonpt_BR
dc.contributor.authorZambelli, Vanessa Olzonpt_BR
dc.contributor.authorPicolo, Giselept_BR
dc.contributor.authorCury, Yarapt_BR
dc.contributor.authorMorandini, André C.pt_BR
dc.contributor.authorMarques, Antonio C.pt_BR
dc.contributor.authorSciani, Juliana Mozerpt_BR
dc.contributor.authorRocha, Thalitapt_BR
dc.date.accessioned2021-06-25T14:26:07Z-
dc.date.available2021-06-25T14:26:07Z-
dc.date.issued2021pt_BR
dc.identifier.citationBueno TC, Collaço RC, Cardoso BA, Bredariol RF, Escobar ML, Cajado IB, et al. Neurotoxicity of Olindias sambaquiensis and Chiropsalmus quadrumanus extracts in sympathetic nervous system. Toxicon. 2021 Aug;199:127-138. doi:10.1016/j.toxicon.2021.06.008.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3864-
dc.description.abstractCnidarians are equipped with nematocysts, which are specialized organelles used to inoculate venom during prey capturing and defense. Their venoms are rich in toxins and a potential source of bioactive compounds, however, poorly explored so far. In this work, the activity of the methanolic extracts from the hydromedusa Olindias sambaquiensis and the cubozoan jellyfish Chiropsalmus quadrumanus were studied in sympathetic neurotransmission. For that, bisected rat vas deferens - a classic model of sympathetic neurotransmission - were incubated with the extracts for further myographic and histopathological analysis. The O. sambaquiensis extract, at 0.1 μg/mL, facilitated the neurogenic contractions of the noradrenergic-rich epididymal portion, while reducing the noradrenaline (NA) potency, which suggests an interaction with postsynaptic α1-adrenoceptors. On the other hand, a higher concentration (1 μg/mL) leads to time- and frequency-dependent blockade of nerve-evoked contractions without significantly changing the response to exogenous NA. In turn, the C. quadrumanus extract at 0.1 μg/mL induced blockade of nerve-evoked noradrenergic contractions while reducing the potency to exogenous NA. Both extracts did not affect the purinergic neurotransmission or induce muscle damages. Our results demonstrate that O. sambaquiensis and C. quadrumanus extracts significantly interfere with the noradrenergic neurotransmission without altering purinergic response or smooth muscle structure on rat vas deferens. Such results bring to light the pharmacological potential of O. sambaquiensis and C. quadrumanus molecules for therapeutics focusing on noradrenergic neurotransmission.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent127-138pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxiconpt_BR
dc.rightsAcesso restritopt_BR
dc.titleNeurotoxicity of Olindias sambaquiensis and Chiropsalmus quadrumanus extracts in sympathetic nervous systempt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.toxicon.2021.06.008pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.toxicon.2021.06.008pt_BR
dc.contributor.externalUniversidade São Francisco (USF)pt_BR
dc.contributor.externalUniversidade Estadual de Campinas (UNICAMP)pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.identifier.citationvolume199pt_BR
dc.subject.keywordCnidarian moleculespt_BR
dc.subject.keywordMyographypt_BR
dc.subject.keywordHistopathologypt_BR
dc.subject.keywordNeurotoxinspt_BR
dc.subject.keywordSympathetic neurotransmissionpt_BR
dc.subject.keywordBioprospectionpt_BR
dc.relation.ispartofabbreviatedToxiconpt_BR
dc.identifier.citationabntv. 199, p. 127-138, ago. 2021pt_BR
dc.identifier.citationvancouver2021 Aug;199:127-138pt_BR
dc.contributor.butantanZambelli, Vanessa Olzon|:Pesquisador|:LEDS - Laboratório de Dor e Sinalização|:Autor de correspondênciapt_BR
dc.contributor.butantanPicolo, Gisele|:Pesquisador|:LEDS - Laboratório de Dor e Sinalização|:Autor de correspondênciapt_BR
dc.contributor.butantanCury, Yara|:Pesquisador|:Laboratório Especial de Dor e Sinalização (LEDS)|:Autor de correspondênciapt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦888872862222/2018–00pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07467–1pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦309995/2017–5pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦309440/2019–0pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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