Crotalus durissus ruruima: current knowledge on natural history, medical importance, and clinical toxinology

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dc.contributorCentro Bioindustrialpt_BR
dc.contributor.authorPucca, Manuela B.pt_BR
dc.contributor.authorBernarde, Paulo Sérgiopt_BR
dc.contributor.authorRocha, Anderson Macielpt_BR
dc.contributor.authorViana, Patrik F.pt_BR
dc.contributor.authorFarias, Raimundo Erasmo Souzapt_BR
dc.contributor.authorCerni, Felipe A.pt_BR
dc.contributor.authorOliveira, Isadora S.pt_BR
dc.contributor.authorFerreira, Isabela G.pt_BR
dc.contributor.authorSandri, Eliseu A.pt_BR
dc.contributor.authorSachett, Jacquelinept_BR
dc.contributor.authorFan, Hui Wenpt_BR
dc.contributor.authorSampaio, Vandersonpt_BR
dc.contributor.authorLaustsen, Andreas H.pt_BR
dc.contributor.authorSartim, Marco A.pt_BR
dc.contributor.authorMonteiro, Wuelton M.pt_BR
dc.date.accessioned2021-07-02T17:02:02Z-
dc.date.available2021-07-02T17:02:02Z-
dc.date.issued2021pt_BR
dc.identifier.citationPucca MB., Bernarde PS, Rocha AM, Viana PF., Farias RES, Cerni FA., et al. Crotalus durissus ruruima: current knowledge on natural history, medical importance, and clinical toxinology. Front. Immunol.. 2021 June;12:659515. doi:10.3389/fimmu.2021.659515.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3874-
dc.description.abstractCrotalus durissus ruruima is a rattlesnake subspecies mainly found in Roraima, the northernmost state of Brazil. Envenomings caused by this subspecies lead to severe clinical manifestations (e.g. respiratory muscle paralysis, rhabdomyolysis, and acute renal failure) that can lead to the victim’s death. In this review, we comprehensively describe C. d. ruruima biology and the challenges this subspecies poses for human health, including morphology, distribution, epidemiology, venom cocktail, clinical envenoming, and the current and future specific treatment of envenomings by this snake. Moreover, this review presents maps of the distribution of the snake subspecies and evidence that this species is responsible for some of the most severe envenomings in the country and causes the highest lethality rates. Finally, we also discuss the efficacy of the Brazilian horse-derived antivenoms to treat C. d. ruruima envenomings in Roraima state.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)pt_BR
dc.description.sponsorshipHamish Ogston Foundationpt_BR
dc.format.extent659515pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofFrontiers in Immunologypt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleCrotalus durissus ruruima: current knowledge on natural history, medical importance, and clinical toxinologypt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3389/fimmu.2021.659515pt_BR
dc.identifier.urlhttps://doi.org/10.3389/fimmu.2021.659515pt_BR
dc.contributor.externalUniversidade Federal de Roraima (UFRR)pt_BR
dc.contributor.externalUniversidade Federal do Acre (UFAC)pt_BR
dc.contributor.externalFaculdade Cathedralpt_BR
dc.contributor.externalInstituto Nacional de Pesquisas da Amazônia (INPA)pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.contributor.externalUniversidade do Estado do Amazonas (UEA)pt_BR
dc.contributor.externalFundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD)pt_BR
dc.contributor.externalUniversity of Denmarkpt_BR
dc.contributor.externalUniversidade Federal do Amazonas (UFAM)pt_BR
dc.identifier.citationvolume12pt_BR
dc.subject.keywordCrotalus durissuspt_BR
dc.subject.keywordCrotalus durissus ruruimapt_BR
dc.subject.keywordrattlesnakept_BR
dc.subject.keywordsnakebitept_BR
dc.subject.keywordenvenomingpt_BR
dc.subject.keywordvenompt_BR
dc.subject.keywordantivenompt_BR
dc.relation.ispartofabbreviatedFront. Immunol.pt_BR
dc.identifier.citationabntv. 12, 659515, jun. 2021pt_BR
dc.identifier.citationvancouver2021 June;12:659515pt_BR
dc.contributor.butantanFan, Hui Wen|:Pesquisador|:Centro Bioindustrialpt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/03580-9pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/14035-1pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦307184/2020-0pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦309207/2020-7pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦001pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)¦¦005/2019pt_BR
dc.sponsorship.butantanHamish Ogston Foundation¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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