Xyloglucan processing machinery in Xanthomonas pathogens and its role in the transcriptional activation of virulence factors

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dc.contributorLab. Desenvolvimento e Inovação Industrialpt_BR
dc.contributor.authorVieira, Plinio S.pt_BR
dc.contributor.authorBonfim, Isabela M.pt_BR
dc.contributor.authorAraujo, Evandro A.pt_BR
dc.contributor.authorMelo, Ricardo R.pt_BR
dc.contributor.authorLima, Augusto R.pt_BR
dc.contributor.authorFessel, Melissa Reginapt_BR
dc.contributor.authorPaixão, Douglas A. A.pt_BR
dc.contributor.authorPersinoti, Gabriela F.pt_BR
dc.contributor.authorRocco, Silvana A.pt_BR
dc.contributor.authorLima, Tatiani B.pt_BR
dc.contributor.authorPirolla, Renan A. S.pt_BR
dc.contributor.authorMorais, Mariana A. B.pt_BR
dc.contributor.authorCorrea, Jessica B. L.pt_BR
dc.contributor.authorZanphorlin, Leticia M.pt_BR
dc.contributor.authorDiogo, Jose A.pt_BR
dc.contributor.authorLima, Evandro A.pt_BR
dc.contributor.authorGrandis, Adrianapt_BR
dc.contributor.authorBuckeridge, Marcos S.pt_BR
dc.contributor.authorGozzo, Fabio C.pt_BR
dc.contributor.authorBenedetti, Celso E.pt_BR
dc.contributor.authorPolikarpov, Igorpt_BR
dc.contributor.authorGiuseppe, Priscila O.pt_BR
dc.contributor.authorMurakami, Mario T.pt_BR
dc.date.accessioned2021-07-08T19:49:39Z-
dc.date.available2021-07-08T19:49:39Z-
dc.date.issued2021pt_BR
dc.identifier.citationVieira PS., Bonfim IM., Araujo EA., Melo RR., Lima AR., Fessel MR., et al. Xyloglucan processing machinery in Xanthomonas pathogens and its role in the transcriptional activation of virulence factors. Nat. Commun.. 2021 June;12:4049. doi:10.1038/s41467-021-24277-4.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3884-
dc.description.abstractXyloglucans are highly substituted and recalcitrant polysaccharides found in the primary cell walls of vascular plants, acting as a barrier against pathogens. Here, we reveal that the diverse and economically relevant Xanthomonas bacteria are endowed with a xyloglucan depolymerization machinery that is linked to pathogenesis. Using the citrus canker pathogen as a model organism, we show that this system encompasses distinctive glycoside hydrolases, a modular xyloglucan acetylesterase and specific membrane transporters, demonstrating that plant-associated bacteria employ distinct molecular strategies from commensal gut bacteria to cope with xyloglucans. Notably, the sugars released by this system elicit the expression of several key virulence factors, including the type III secretion system, a membrane-embedded apparatus to deliver effector proteins into the host cells. Together, these findings shed light on the molecular mechanisms underpinning the intricate enzymatic machinery of Xanthomonas to depolymerize xyloglucans and uncover a role for this system in signaling pathways driving pathogenesis.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent4049pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofNature Communicationspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleXyloglucan processing machinery in Xanthomonas pathogens and its role in the transcriptional activation of virulence factorspt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.1038/s41467-021-24277-4pt_BR
dc.identifier.urlhttps://doi.org/10.1038/s41467-021-24277-4pt_BR
dc.contributor.externalCentro Nacional de Pesquisa em Energia e Materiais (CNPEM)pt_BR
dc.contributor.externalLaboratório Nacional de Biorrenováveis (LNBR)pt_BR
dc.contributor.externalUniversidade Estadual de Campinas (UNICAMP)pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.identifier.citationvolume12pt_BR
dc.subject.keywordBacterial physiologypt_BR
dc.subject.keywordBacterial structural biologypt_BR
dc.subject.keywordGlycobiologypt_BR
dc.subject.keywordPathogenspt_BR
dc.relation.ispartofabbreviatedNat. Commun.pt_BR
dc.identifier.citationabntv. 12, 4049, jun. 2021pt_BR
dc.identifier.citationvancouver2021 June;12:4049pt_BR
dc.contributor.butantanFessel, Melissa Regina|:Técnico|:Lab. Desenvolvimento e Inovação Industrialpt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/26982-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/13684-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/06509-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/14253-9pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/19995-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2019/13936-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/00203-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/03724-3pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦303988-2015-5pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦408600/2018-7pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦158752/2015-5pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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