Endoplasmic reticulum stress and autophagy markers in Soleus muscle disuse-induced atrophy of rats treated with fish oil

Full metadata record
DC FieldValueLanguage
dc.contributorDiretoria Técnicapt_BR
dc.contributor.authorMarzuca-Nassr, Gabriel Nasript_BR
dc.contributor.authorKuwabara, Wilson Mitsuo Tatagibapt_BR
dc.contributor.authorVitzel, Kaio Fernandopt_BR
dc.contributor.authorMurata, Gilson Masahiropt_BR
dc.contributor.authorTorres, Rosângela Pavanpt_BR
dc.contributor.authorMancini-Filho, Jorgept_BR
dc.contributor.authorAlba-Loureiro, Tatiana Carolinapt_BR
dc.contributor.authorCuri, Ruipt_BR
dc.date.accessioned2021-08-04T19:31:55Z-
dc.date.available2021-08-04T19:31:55Z-
dc.date.issued2021pt_BR
dc.identifier.citationMarzuca-Nassr GN, Kuwabara WMT, Vitzel KF, Murata GM, Torres RP, Mancini-Filho J, et al. Endoplasmic reticulum stress and autophagy markers in soleus muscle disuse-induced atrophy of rats treated with fish oil. Nutrients. 2021 July;13(7):2298. doi:10.3390/nu13072298.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3910-
dc.description.abstractEndoplasmic reticulum stress (ERS) and autophagy pathways are implicated in disuse muscle atrophy. The effects of high eicosapentaenoic (EPA) or high docosahexaenoic (DHA) fish oils on soleus muscle ERS and autophagy markers were investigated in a rat hindlimb suspension (HS) atrophy model. Adult Wistar male rats received daily by gavage supplementation (0.3 mL per 100 g b.w.) of mineral oil or high EPA or high DHA fish oils (FOs) for two weeks. Afterward, the rats were subjected to HS and the respective treatments concomitantly for an additional two-week period. After four weeks, we evaluated ERS and autophagy markers in the soleus muscle. Results were analyzed using two-way analysis of variance (ANOVA) and Bonferroni post hoc test. Gastrocnemius muscle ω-6/ω-3 fatty acids (FAs) ratio was decreased by both FOs indicating the tissue incorporation of omega-3 fatty acids. HS altered (p < 0.05) the protein content (decreasing total p38 and BiP and increasing p-JNK2/total JNK2 ratio, and caspase 3) and gene expressions (decreasing BiP and increasing IRE1 and PERK) of ERS and autophagy (decreasing Beclin and increasing LC3 and ATG14) markers in soleus. Both FOs attenuated (p < 0.05) the increase in PERK and ATG14 expressions induced by HS. Thus, both FOs could potentially attenuate ERS and autophagy in skeletal muscles undergoing atrophy.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorship(JSGMF) John Simon Guggenheim Memorial Foundationpt_BR
dc.description.sponsorship(FONDECYT) Fondo Nacional de Desarrollo Científico y Tecnológicopt_BR
dc.description.sponsorship(CONICYT) Comisión Nacional de Investigación Científica y Tecnológicapt_BR
dc.format.extent2298pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofNutrientspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleEndoplasmic reticulum stress and autophagy markers in Soleus muscle disuse-induced atrophy of rats treated with fish oilpt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3390/nu13072298pt_BR
dc.identifier.urlhttps://doi.org/10.3390/nu13072298pt_BR
dc.contributor.externalUniversidad de La Fronterapt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.externalMassey Universitypt_BR
dc.contributor.external(UNICSUL) Universidade Cruzeiro do Sulpt_BR
dc.identifier.citationvolume13pt_BR
dc.identifier.citationissue7pt_BR
dc.subject.keywordω-3 fatty acidspt_BR
dc.subject.keywordeicosapentanoic acidpt_BR
dc.subject.keyworddocosahexaenoic acidpt_BR
dc.subject.keywordhindlimb suspensionpt_BR
dc.subject.keywordskeletal muscle atrophypt_BR
dc.subject.keywordunfolded protein responsept_BR
dc.relation.ispartofabbreviatedNutrientspt_BR
dc.identifier.citationabntv. 13, n. 7, 2298, jul. 2021pt_BR
dc.identifier.citationvancouver2021 July;13(7):2298pt_BR
dc.contributor.butantanCuri, Rui|:Outros|:Diretoria Técnicapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦pt_BR
dc.sponsorship.butantan(JSGMF) John Simon Guggenheim Memorial Foundation¦¦pt_BR
dc.sponsorship.butantan(FONDECYT) Fondo Nacional de Desarrollo Científico y Tecnológico¦¦11180949pt_BR
dc.sponsorship.butantanComisión Nacional de Investigación Científica y Tecnológica (CONICYT)¦¦72130103pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1English-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journalissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journaleissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
Appears in Collections:Artigos de periódicos


Files in This Item:

nutrients-13-02298.pdf
Description:
Size: 2.69 MB
Format: Adobe PDF
View/Open
Show simple item record

This item is licensed under a Creative Commons License Creative Commons