Prefrontal cortex and hippocampus inflammation in mice fed high-carbohydrate or high-fat diets

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dc.contributorCentro Bioindustrialpt_BR
dc.contributor.authorAntunes, Marina Masettopt_BR
dc.contributor.authorGodoy, Guilhermept_BR
dc.contributor.authorMasi, Laureane Nunespt_BR
dc.contributor.authorCuri, Ruipt_BR
dc.contributor.authorBazotte, Roberto Barbosapt_BR
dc.date.accessioned2021-09-23T16:01:17Z-
dc.date.available2021-09-23T16:01:17Z-
dc.date.issued2022pt_BR
dc.identifier.citationAntunes MM, Godoy G, Masi LN, Curi R, Bazotte RB. Prefrontal cortex and hippocampus inflammation in mice fed high-carbohydrate or high-fat diets. J Med Food. 2022 Jan;25(1):110-113. doi:10.1089/jmf.2021.0026.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3942-
dc.description.abstractWe previously reported that a high-carbohydrate diet (HCD) induced systemic inflammation and higher gene expression of proinflammatory mediators in the liver, skeletal muscle, and brain than a high-fat diet (HFD). However, the differences between the groups were less pronounced in the brain. In this study, we extended the evaluation of inflammation to specific areas of the brain. In this study, we evaluated the gene expression of caspase 2, caspase 3, caspase 9, cyclooxygenase-2 (Cox 2), inducible nitric oxide synthase (iNOS), interleukin (IL), IL-6, IL-1β, IL-10, IL-4, tumor necrosis factor-alpha (TNF-α), integrin subunit alpha m (Itgam), S100 protein (S100), allograft inflammatory factor 1 (Aif1), and glial fibrillary acidic protein (Gfap) in the prefrontal cortex and hippocampus of male Swiss mice that were fed with HCD or HFD for 8 weeks. The HCD group exhibited higher IL-1β expression, whereas the HFD group showed higher TNF-α expression in the prefrontal cortex. In the hippocampus, TNF-α expression was higher in the HFD group. IL-1β and TNF-α are proinflammatory cytokines that have been associated with impaired brain function and numerous brain disorders. Our results indicate that both HCD and HFD promote prefrontal cortex inflammation; however, the hippocampus seems more sensitive to a HFD than HCD.pt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.extent110-113pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofJournal of Medicinal Foodpt_BR
dc.rightsRestricted accesspt_BR
dc.titlePrefrontal cortex and hippocampus inflammation in mice fed high-carbohydrate or high-fat dietspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1089/jmf.2021.0026pt_BR
dc.identifier.urlhttps://doi.org/10.1089/jmf.2021.0026pt_BR
dc.contributor.external(UEM) Universidade Estadual de Maringápt_BR
dc.contributor.external(UNICSUL) Universidade Cruzeiro do Sulpt_BR
dc.identifier.citationvolume25pt_BR
dc.identifier.citationissue1pt_BR
dc.subject.keywordbrain inflammationpt_BR
dc.subject.keywordcytokinespt_BR
dc.subject.keywordIL-1βpt_BR
dc.subject.keywordmacronutrientspt_BR
dc.subject.keywordneuroinflammationpt_BR
dc.subject.keywordTNF-αpt_BR
dc.relation.ispartofabbreviatedJ Med Foodpt_BR
dc.identifier.citationabntv. 25, n. 1, p. 110-113, jan. 2022pt_BR
dc.identifier.citationvancouver2022 Jan;25(1):110-113pt_BR
dc.contributor.butantanMasi, Laureane Nunes|:Desvinculado|:Centro Bioindustrialpt_BR
dc.contributor.butantanCuri, Rui|:Outros|:Centro Bioindustrialpt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦88882.448882/2019-01pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦88882.448894/2019-01pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/09868-7pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/25892-8pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.grantfulltextembargo_29990101-
item.languageiso639-1English-
item.fulltextCom Texto completo-
item.openairetypeArticle-
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