MicroRNA roles in regeneration: multiple lessons from zebrafish

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dc.contributorLaboratório de Toxinologia Aplicadapt_BR
dc.contributorCeTICS - Centro de Toxinas, Resposta-imune e Sinalização Celularpt_BR
dc.contributor.authorRibeiro, Amanda Oliveirapt_BR
dc.contributor.authorOliveira, Arthur Casulli dept_BR
dc.contributor.authorCosta, Juliana Marapt_BR
dc.contributor.authorNachtigall, Pedro Gabrielpt_BR
dc.contributor.authorHerkenhoff, Marcos Edgarpt_BR
dc.contributor.authorCampos, Vinicius Fariaspt_BR
dc.contributor.authorDelella, Flávia Karinapt_BR
dc.contributor.authorPinhal, Danillopt_BR
dc.date.accessioned2021-10-08T14:47:56Z-
dc.date.available2021-10-08T14:47:56Z-
dc.date.issued2021pt_BR
dc.identifier.citationRibeiro AO, Oliveira AC, Costa JM, Nachtigall PG, Herkenhoff ME, Campos VF, et al. MicroRNA roles in regeneration: Multiple lessons from zebrafish. Dev Dyn. 2021 Sept;in press. doi:10.1002/dvdy.421.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3954-
dc.description.abstractMicroRNAs (miRNAs) are small noncoding RNAs with pivotal roles in the control of gene expression. By comparing the miRNA profiles of uninjured vs. regenerating tissues and structures, several studies have found that miRNAs are potentially involved in the regenerative process. By inducing miRNA overexpression or inhibition, elegant experiments have directed regenerative responses validating relevant miRNA-to-target interactions. The zebrafish (Danio rerio) has been the epicenter of regenerative research because of its exceptional capability to self-repair damaged tissues and body structures. In this review, we discuss recent discoveries that have improved our understanding of the impact of gene regulation mediated by miRNAs in the context of the regeneration of fins, heart, retina, and nervous tissue in zebrafish. We compiled what is known about the miRNA control of regeneration in these tissues and investigated the links among up-regulated and down-regulated miRNAs, their putative or validated targets, and the regenerative process. Finally, we briefly discuss the forthcoming prospects, highlighting directions and the potential for further development of this field.pt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(FAPERGS) Fundação de Amparo à pesquisa do Estado do Rio Grande do Sulpt_BR
dc.format.extent556-576pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofDevelopmental dynamicspt_BR
dc.rightsRestricted accesspt_BR
dc.titleMicroRNA roles in regeneration: multiple lessons from zebrafishpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1002/dvdy.421pt_BR
dc.identifier.urlhttps://doi.org/10.1002/dvdy.421pt_BR
dc.contributor.external(UNESP) Universidade Estadual Paulista Júlio de Mesquita Filhopt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.externalUniversidade Federal de Pelotaspt_BR
dc.identifier.citationvolume251pt_BR
dc.identifier.citationissue4pt_BR
dc.subject.keywordfinspt_BR
dc.subject.keywordheartpt_BR
dc.subject.keywordmiRNAspt_BR
dc.subject.keywordnervous tissuept_BR
dc.subject.keywordretinapt_BR
dc.relation.ispartofabbreviatedDev Dynpt_BR
dc.identifier.citationabntv. 251, n. 4, p. 556-576, set. 2021pt_BR
dc.identifier.citationvancouver2021 Sept251(4):556-576pt_BR
dc.contributor.butantanNachtigall, Pedro Gabriel|:Pós-Doc|:Laboratório de Toxinologia Aplicada:CeTICS - Centro de Toxinas, Resposta-imune e Sinalização Celularpt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦158284/2013-5pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2013/06864-7pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2014/03062-0pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/05484-0pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/14348-2pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/15494-5pt_BR
dc.sponsorship.butantanFundação de Amparo à pesquisa do Estado do Rio Grande do Sul (FAPERGS)¦¦17/2551-0000953-3pt_BR
dc.sponsorship.butantanFundação de Amparo à pesquisa do Estado do Rio Grande do Sul (FAPERGS)¦¦19/2551-0002283-2pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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