Simultaneous expression of UV and violet SWS1 opsins expands the visual palette in a group of freshwater snakes

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dc.contributorCeTICS - Centro de Toxinas, Resposta-imune e Sinalização Celularpt_BR
dc.contributorLaboratório de Toxinologia Aplicadapt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.authorHauzman, Einatpt_BR
dc.contributor.authorPierotti, Michele E Rpt_BR
dc.contributor.authorBhattacharyya, Niharpt_BR
dc.contributor.authorTashiro, Juliana Hpt_BR
dc.contributor.authorYovanovich, Carola A Mpt_BR
dc.contributor.authorCampos, Pollyanna Fernandespt_BR
dc.contributor.authorVentura, Dora Fpt_BR
dc.contributor.authorChang, Belinda S Wpt_BR
dc.date.accessioned2021-10-19T17:08:17Z-
dc.date.available2021-10-19T17:08:17Z-
dc.date.issued2021pt_BR
dc.identifier.citationHauzman E, Pierotti MER, Bhattacharyya N, Tashiro JH, Yovanovich CAM, Campos PF, et al. Simultaneous expression of UV and violet SWS1 opsins expands the visual palette in a group of freshwater snakes. Mol. Biol. Evol.. 2021 Sept;38(12):5225–5240. doi:10.1093/molbev/msab285.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3957-
dc.description.abstractSnakes are known to express a rod visual opsin and two cone opsins, only (SWS1, LWS), a reduced palette resulting from their supposedly fossorial origins. Dipsadid snakes in the genus Helicops are highly visual predators that successfully invaded freshwater habitats from ancestral terrestrial-only habitats. Here, we report the first case of multiple SWS1 visual pigments in a vertebrate, simultaneously expressed in different photoreceptors and conferring both UV and violet sensitivity to Helicops snakes. Molecular analysis and in vitro expression confirmed the presence of two functional SWS1 opsins, likely the result of recent gene duplication. Evolutionary analyses indicate that each sws1 variant has undergone different evolutionary paths with strong purifying selection acting on the UV-sensitive copy and dN/dS ∼1 on the violet-sensitive copy. Site-directed mutagenesis points to the functional role of a single amino acid substitution, Phe86Val, in the large spectral shift between UV and violet opsins. In addition, higher densities of photoreceptors and SWS1 cones in the ventral retina suggest improved acuity in the upper visual field possibly correlated with visually guided behaviors. The expanded visual opsin repertoire and specialized retinal architecture are likely to improve photon uptake in underwater and terrestrial environments, and provide the neural substrate for a gain in chromatic discrimination, potentially conferring unique color vision in the UV–violet range. Our findings highlight the innovative solutions undertaken by a highly specialized lineage to tackle the challenges imposed by the invasion of novel photic environments and the extraordinary diversity of evolutionary trajectories taken by visual opsin-based perception in vertebrates.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada (NSERC)pt_BR
dc.format.extent5225–5240pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofMolecular Biology and Evolutionpt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleSimultaneous expression of UV and violet SWS1 opsins expands the visual palette in a group of freshwater snakespt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.1093/molbev/msab285pt_BR
dc.identifier.urlhttps://doi.org/10.1093/molbev/msab285pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.externalHospital Israelita Albert Einsteinpt_BR
dc.contributor.externalUniversity of Torontopt_BR
dc.contributor.externalUniversity of Sussexpt_BR
dc.identifier.citationvolume38pt_BR
dc.identifier.citationissue12pt_BR
dc.subject.keywordretinapt_BR
dc.subject.keywordvisual pigmentspt_BR
dc.subject.keywordopsinspt_BR
dc.subject.keywordSWS1pt_BR
dc.subject.keywordspectral tuningpt_BR
dc.relation.ispartofabbreviatedMol. Biol. Evol.pt_BR
dc.identifier.citationabntv. 38, n. 12, p. 5225–5240, set. 2021pt_BR
dc.identifier.citationvancouver2021 Sept;38(12):5225–5240pt_BR
dc.contributor.butantanCampos, Pollyanna Fernandes|:Pós-Doc|:CeTICS - Centro de Toxinas, Resposta-imune e Sinalização Celular:Laboratório de Toxinologia Aplicadapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2014/25743-9pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/09321-8pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2014/26818-2pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/11502-0pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/13910-9pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2015/14857-6pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦08307/03/2013pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦309409/2015-2pt_BR
dc.sponsorship.butantanNatural Sciences and Engineering Research Council of Canada (NSERC)¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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