Genomic analysis of an outbreak of bovine tuberculosis in a man-made multi-host species system: a call for action on wildlife in Brazil

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dc.contributor(LCC) Laboratório de Ciclo Celularpt_BR
dc.contributor.authorLima, Daiane A. R.pt_BR
dc.contributor.authorZimpel, Cristina K.pt_BR
dc.contributor.authorPatané, José Salvatore Leisterpt_BR
dc.contributor.authorSilva-Pereira, Taiana Tainápt_BR
dc.contributor.authorEtges, Rodrigo N.pt_BR
dc.contributor.authorRodrigues, Rudielle A.pt_BR
dc.contributor.authorDávila, Alberto M.R.pt_BR
dc.contributor.authorIkuta, Cássia Y.pt_BR
dc.contributor.authorFerreira Neto, José S.pt_BR
dc.contributor.authorGuimarães, Ana Marcia S.pt_BR
dc.contributor.authorAraújo, Flábio R.pt_BR
dc.date.accessioned2021-11-10T20:55:18Z-
dc.date.available2021-11-10T20:55:18Z-
dc.date.issued2021pt_BR
dc.identifier.citationLima DA.R., Zimpel CK., Patané JSL, Silva-Pereira TT, Etges RN., Rodrigues RA., et al. Genomic analysis of an outbreak of bovine tuberculosis in a man-made multi-host species system: a call for action on wildlife in Brazil. Transbound. Emerg. Dis.. 2021 Out;in press. doi:10.1111/tbed.14343.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3970-
dc.description.abstractWe report on a 15-year-long outbreak of bovine tuberculosis (bTB) in wildlife from a Brazilian safari park. A timeline of diagnostic events and whole-genome sequencing (WGS) of 21 Mycobacterium bovis isolates from deer and llamas were analyzed. Accordingly, from 2003 to 2018, at least 16 animals, from eight species, died due to TB, which is likely an underestimated number. In three occasions since 2013, the deer presented positive tuberculin tests, leading to the park closure and culling of all deer. WGS indicated that multiple M. bovis strains were circulating, with at least three founding introductions since the park inauguration in 1977. Using a previously sequenced dataset of 71 M. bovis genomes from cattle, we found no recent transmission events between nearby farms and the park based on WGS. Lastly, by discussing socio-economic and environmental factors escaping current regulatory gaps that were determinant of this outbreak, we pledge for the development of a plan to report and control bTB in wildlife in Brazil.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipMorris Animal Foundationpt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorship(FUNDECT) Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sulpt_BR
dc.format.extent1-12pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofTransboundary and Emerging Diseasespt_BR
dc.rightsRestricted accesspt_BR
dc.titleGenomic analysis of an outbreak of bovine tuberculosis in a man-made multi-host species system: a call for action on wildlife in Brazilpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1111/tbed.14343pt_BR
dc.identifier.urlhttps://doi.org/10.1111/tbed.14343pt_BR
dc.contributor.external(UFMS) Universidade Federal de Mato Grosso do Sulpt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.externalSecretaria da Agricultura, Pecuária e Desenvolvimento Ruralpt_BR
dc.contributor.external(IOC) Instituto Oswaldo Cruzpt_BR
dc.contributor.externalEmbrapa Gado de Cortept_BR
dc.identifier.citationvolume2021pt_BR
dc.subject.keywordbovine tuberculosipt_BR
dc.subject.keywordgenomicspt_BR
dc.subject.keywordMycobacterium bovispt_BR
dc.subject.keywordpublic health policiespt_BR
dc.subject.keywordwildlifept_BR
dc.relation.ispartofabbreviatedTransbound. Emerg. Dis.pt_BR
dc.identifier.citationabntv. 2021, p. 1-12, out. 2021pt_BR
dc.identifier.citationvancouver2021 Out;2021:1-12pt_BR
dc.contributor.butantanPatané, José Salvatore Leister|:Técnico|:LCC - Laboratório de Ciclo Celularpt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/10896-8pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/04617-3pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦443235/2014-7pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦407826/2018-1pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦306675/2018-8pt_BR
dc.sponsorship.butantanMorris Animal Foundation¦¦D17ZO-307pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦001pt_BR
dc.sponsorship.butantanFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT)¦¦59/300.104/2017pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
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item.languageiso639-1English-
item.grantfulltextembargo_29990101-
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