Identification of leptospiral protein antigens recognized by WC1+ γδ T cell subsets as target for development of recombinant vaccines

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dc.contributor(LDV) Lab. Desenvolvimento de Vacinaspt_BR
dc.contributor.authorTeixeira, Aline Rodrigues Florênciopt_BR
dc.contributor.authorGillespie, Alexandriapt_BR
dc.contributor.authorYirsaw, Alehegnept_BR
dc.contributor.authorBritton, Emilypt_BR
dc.contributor.authorTelfer, Janice C.pt_BR
dc.contributor.authorNascimento, Ana Lúcia Tabet Oller dopt_BR
dc.contributor.authorBaldwin, Cynthia L.pt_BR
dc.identifier.citationTeixeira ARF, Gillespie A, Yirsaw A, Britton E, Telfer JC., Nascimento ALTO, et al. Identification of leptospiral protein antigens recognized by WC1+ γδ T cell subsets as target for development of recombinant vaccines. Infect. Immun.. 2021 Oct90(1):e00492-21. doi:10.1128/iai.00492-21.pt_BR
dc.description.abstractPathogenic Leptospira species cause leptospirosis, a neglected zoonotic disease recognized as a global public health problem. It is also the cause of the most common cattle infection that results in major economic losses due to reproductive problems. γδ T cells play a role in the protective immune response in livestock species against Leptospira while human γδ T cells also respond to Leptospira. Thus, activation of γδ T cells has emerged as a potential component in the optimization of vaccine strategies. Bovine γδ T cells proliferate and produce IFN-γ in response to vaccination with inactivated leptospires and this response is mediated by a specific subpopulation of the WC1-bearing γδ T cells. WC1 molecules are members of the group B scavenger receptor cysteine rich (SRCR) superfamily and are composed of multiple SRCR domains, of which particular extracellular domains act as ligands for Leptospira. Since WC1 molecules function as both pattern recognition receptors and γδ TCR coreceptors, the WC1 system has been proposed as a novel target to engage γδ T cells. Here, we demonstrate the involvement of leptospiral protein antigens in the activation of WC1+ γδ T cells and identified two leptospiral outer membrane proteins able to interact directly with them. Interestingly, we show that the protein-specific γδ T cell response is composed of WC1.1+ and WC1.2+ subsets, although a greater number of WC1.1+ ???? T-cell respond. Identification of protein antigens will enhance our understanding of the role γδ T cells play in the leptospiral immune response and in recombinant vaccine development.pt_BR
dc.description.sponsorship(NIFA) National Institute of Food and Agriculturept_BR
dc.description.sponsorship(CAFE) Center for Agriculture, Food and the Environmentpt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.relation.ispartofInfection and immunitypt_BR
dc.rightsRestricted accesspt_BR
dc.titleIdentification of leptospiral protein antigens recognized by WC1+ γδ T cell subsets as target for development of recombinant vaccinespt_BR
dc.contributor.externalUniversity of Massachusettspt_BR
dc.subject.keywordγδ T cellspt_BR
dc.relation.ispartofabbreviatedInfect Immunpt_BR
dc.identifier.citationabntv. 90, n. 1, e00492-21, out. 2021pt_BR
dc.identifier.citationvancouver2021 Oct;90(1):e00492-21pt_BR
dc.contributor.butantanTeixeira, Aline Rodrigues Florêncio|:Pós-Doc|:(LDV) Lab. de Desenvolvimento de Vacinas|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanNascimento, Ana Lúcia Tabet Oller do|:Pesquisador|:(LDV) Lab. de Desenvolvimento de Vacinaspt_BR
dc.sponsorship.butantanNational Institute of Food and Agriculture¦¦2016-09379pt_BR
dc.sponsorship.butantanCenter for Agriculture, Food and the Environment (CAFE)¦¦2016-67015-24913pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2019/05466-4pt_BR
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