Exosomes in the tumor microenvironment: from biology to clinical applications

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dc.contributor(LG) Laboratório de Genéticapt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.authorCosta, Vitor Rodrigues dapt_BR
dc.contributor.authorAraldi, Rodrigo Pinheiropt_BR
dc.contributor.authorVigerelli, Hugopt_BR
dc.contributor.authorD’Amélio, Fernandapt_BR
dc.contributor.authorMendes, Thais Biudept_BR
dc.contributor.authorGonzaga, Vivianpt_BR
dc.contributor.authorPoliciquio, Bruna De Oliveirapt_BR
dc.contributor.authorColozza-Gama, Gabriel Avelarpt_BR
dc.contributor.authorValverde , Cristiane Wenceslaupt_BR
dc.contributor.authorKerkis, Irinapt_BR
dc.date.accessioned2021-11-12T20:39:42Z-
dc.date.available2021-11-12T20:39:42Z-
dc.date.issued2021pt_BR
dc.identifier.citationCosta VR, Araldi RP, Vigerelli H, D’Amélio F, Mendes TB, Gonzaga V, et al. Exosomes in the tumor microenvironment: from biology to clinical applications. Cells. 2021 Oct;10(10):2617. doi:10.3390/cells10102617.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3978-
dc.description.abstractCancer is one of the most important health problems and the second leading cause of death worldwide. Despite the advances in oncology, cancer heterogeneity remains challenging to therapeutics. This is because the exosome-mediated crosstalk between cancer and non-cancer cells within the tumor microenvironment (TME) contributes to the acquisition of all hallmarks of cancer and leads to the formation of cancer stem cells (CSCs), which exhibit resistance to a range of anticancer drugs. Thus, this review aims to summarize the role of TME-derived exosomes in cancer biology and explore the clinical potential of mesenchymal stem-cell-derived exosomes as a cancer treatment, discussing future prospects of cell-free therapy for cancer treatment and challenges to be overcome.pt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.extent2617pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofCellspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleExosomes in the tumor microenvironment: from biology to clinical applicationspt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3390/cells10102617pt_BR
dc.identifier.urlhttps://doi.org/10.3390/cells10102617pt_BR
dc.contributor.external(UNIFESP) Universidade Federal de São Paulopt_BR
dc.contributor.externalCellavita Pesquisas Científicaspt_BR
dc.identifier.citationvolume10pt_BR
dc.identifier.citationissue10pt_BR
dc.subject.keywordexosomespt_BR
dc.subject.keywordcancerpt_BR
dc.subject.keywordtumor microenvironment (TME)pt_BR
dc.subject.keywordimmunomodulationpt_BR
dc.subject.keywordepithelial-mesenchymal transition (EMT)pt_BR
dc.subject.keywordmesenchymal-stem cell (MSC)pt_BR
dc.subject.keywordcell-free therapypt_BR
dc.relation.ispartofabbreviatedCellspt_BR
dc.identifier.citationabntv. 10, n. 10, 2617, out. 2021pt_BR
dc.identifier.citationvancouver2021 Oct;10(10):2617pt_BR
dc.contributor.butantanCosta, Vitor Rodrigues da|:Desvinculado|:Lab. Genética|:PrimeiroAutorpt_BR
dc.contributor.butantanAraldi, Rodrigo Pinheiro|:Desvinculado|:Lab. Genéticapt_BR
dc.contributor.butantanVigerelli, Hugo|:Pós-Doc:Docente colaborador PPGTox|:Lab. Genéticapt_BR
dc.contributor.butantanD’Amélio, Fernanda|:Aluno|:Lab. Genética:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.butantanMendes, Thais Biude|:Desvinculado|:Lab. Genéticapt_BR
dc.contributor.butantanGonzaga, Vivian|:Desvinculado|:Lab. Genéticapt_BR
dc.contributor.butantanPoliciquio, Bruna De Oliveira|:Desvinculado|:Lab. Genéticapt_BR
dc.contributor.butantanKerkis, Irina|:Pesquisador:Docente Permanente PPGTox|:Lab. Genética|:Autor de correspondênciapt_BR
dc.sponsorship.butantanFundação Butantan¦¦pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦408037/2018-0pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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