Observation of Bothrops atrox snake envenoming blister formation from five patients: pathophysiological insights

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dc.contributorLab. Imunopatologiapt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributorCentro Bioindustrialpt_BR
dc.contributor.authorGimenes, Sarah Natalie Cirilopt_BR
dc.contributor.authorSachett, Jacqueline A. G.pt_BR
dc.contributor.authorColombini, Mônicapt_BR
dc.contributor.authorFreitas-de-Sousa, Luciana Aparecidapt_BR
dc.contributor.authorIbiapina, Hiochelson N. S.pt_BR
dc.contributor.authorCosta, Allyson G.pt_BR
dc.contributor.authorSantana, Monique F.pt_BR
dc.contributor.authorPark, Jeong-Jinpt_BR
dc.contributor.authorSherman, Nicholas E.pt_BR
dc.contributor.authorFerreira, Luiz C. L.pt_BR
dc.contributor.authorFan, Hui Wenpt_BR
dc.contributor.authorMonteiro, Wuelton M.pt_BR
dc.contributor.authorMoura-da-Silva, Ana Mariapt_BR
dc.contributor.authorFox, Jay W.pt_BR
dc.date.accessioned2021-12-07T19:46:13Z-
dc.date.available2021-12-07T19:46:13Z-
dc.date.issued2021pt_BR
dc.identifier.citationGimenes SNC, Sachett JA.G., Colombini M, Freitas-de-Sousa LA, Ibiapina HN.S., Costa AG., et al. Observation of Bothrops atrox snake envenoming blister formation from five patients: pathophysiological insights. Toxins. 2021 Nov;13(11):800. doi:10.3390/toxins13110800.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/4013-
dc.description.abstractIn the Brazilian Amazon, Bothrops atrox snakebites are frequent, and patients develop tissue damage with blisters sometimes observed in the proximity of the wound. Antivenoms do not seem to impact blister formation, raising questions regarding the mechanisms underlying blister formation. Here, we launched a clinical and laboratory-based study including five patients who followed and were treated by the standard clinical protocols. Blister fluids were collected for proteomic analyses and molecular assessment of the presence of venom and antivenom. Although this was a small patient sample, there appeared to be a correlation between the time of blister appearance (shorter) and the amount of venom present in the serum (higher). Of particular interest was the biochemical identification of both venom and antivenom in all blister fluids. From the proteomic analysis of the blister fluids, all were observed to be a rich source of damage-associated molecular patterns (DAMPs), immunomodulators, and matrix metalloproteinase-9 (MMP-9), suggesting that the mechanisms by which blisters are formed includes the toxins very early in envenomation and continue even after antivenom treatment, due to the pro-inflammatory molecules generated by the toxins in the first moments after envenomings, indicating the need for local treatments with anti-inflammatory drugs plus toxin inhibitors to prevent the severity of the wounds.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(FAPEAM) Fundação de Amparo à Pesquisa do Estado do Amazonaspt_BR
dc.format.extent800pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxinspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleObservation of Bothrops atrox snake envenoming blister formation from five patients: pathophysiological insightspt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3390/toxins13110800pt_BR
dc.identifier.urlhttps://doi.org/10.3390/toxins13110800pt_BR
dc.contributor.external(UEA) Universidade do Estado do Amazonaspt_BR
dc.contributor.external(FUAM) Fundação Alfredo da Mattapt_BR
dc.contributor.external(FMT-HVD) Fundação de Medicina Tropical Doutor Heitor Vieira Douradopt_BR
dc.contributor.external(HEMOAM) Fundação Hospitalar de Hematologia e Hemoterapia do Amazonaspt_BR
dc.contributor.external(UVA) University of Virginiapt_BR
dc.identifier.citationvolume13pt_BR
dc.identifier.citationissue11pt_BR
dc.subject.keywordBothrops atroxpt_BR
dc.subject.keywordblisterpt_BR
dc.subject.keywordlocal damagept_BR
dc.subject.keywordDAMPspt_BR
dc.subject.keywordsnake venompt_BR
dc.subject.keywordantivenompt_BR
dc.subject.keywordsnakebitept_BR
dc.relation.ispartofabbreviatedToxinspt_BR
dc.identifier.citationabntv. 13, n. 11, 800, nov. 2021pt_BR
dc.identifier.citationvancouver2021 Nov;13(11):800pt_BR
dc.contributor.butantanGimenes, Sarah Natalie Cirilo|:Desvinculado|:Lab. Imunopatologia|:PrimeiroAutorpt_BR
dc.contributor.butantanColombini, Mônica|:Técnico|:Lab. Imunopatologiapt_BR
dc.contributor.butantanFreitas-de-Sousa, Luciana Aparecida|:Aluno Egresso|:Lab. Imunopatologia:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.butantanFan, Hui Wen|:Pesquisador|:Centro Bioindustrialpt_BR
dc.contributor.butantanMoura-da-Silva, Ana Maria|:Pesquisador|:Lab. Imunopatologia|:Autor de correspondênciapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/50127-5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/24546-3pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/13108-8pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2019/08208-6pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦303958/2018-9pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)¦¦287/2013pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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