A review on host-leptospira interactions: what we know and future expectations

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dc.contributor(LDV) Lab. Desenvolvimento de Vacinaspt_BR
dc.contributor.authorDaroz, Brendapt_BR
dc.contributor.authorFernandes, Luis Guilherme Vírgíliopt_BR
dc.contributor.authorPereira, Maria Fernanda Cavenaguept_BR
dc.contributor.authorKochi, Leandro Toshiopt_BR
dc.contributor.authorPassalia, Felipe Josépt_BR
dc.contributor.authorTakahashi, Maria Beatrizpt_BR
dc.contributor.authorFilho, Edson Galdino do Nascimentopt_BR
dc.contributor.authorTeixeira, Aline Rodrigues Florênciopt_BR
dc.contributor.authorNascimento, Ana Lúcia Tabet Oller dopt_BR
dc.date.accessioned2021-12-16T18:18:17Z-
dc.date.available2021-12-16T18:18:17Z-
dc.date.issued2021pt_BR
dc.identifier.citationDaroz B, Fernandes LGV, Pereira MFC, Kochi LT, Passalia FJ, Takahashi MB, et al. A review on host-leptospira interactions: what we know and future expectations. Front. Cell. Infect. Microbiol. 2021 Nov;11:777709. doi:10.3389/fcimb.2021.777709.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/4034-
dc.description.abstractLeptospirosis is a widespread zoonosis caused by pathogenic Leptospira spp. It is considered a neglected infectious disease of human and veterinary concern. Our group has been investigating proteins annotated as hypothetical, predicted to be located on the leptospiral surface. Because of their location, these proteins may have the ability to interact with various host components, which could allow establishment of the infection. These proteins act as adherence factors by binding to host receptor molecules, such as the extracellular matrix (ECM) components laminin and glycosaminoglycans to help bacterial colonization. Leptospira also interacts with the host fibrinolytic system, which has been demonstrated to be a powerful tool for invasion mechanisms. The interaction with fibrinogen and thrombin has been shown to reduce fibrin clot formation. Additionally, the degradation of coagulation cascade components by secreted proteases or by acquired surface plasmin could also play a role in reducing clot formation, hence facilitating dissemination during infection. Interaction with host complement system regulators also plays a role in helping bacteria to evade the immune system, facilitating invasion. Interaction of Leptospira to cell receptors, such as cadherins, can contribute to investigate molecules that participate in virulence. To achieve a better understanding of the host-pathogen interaction, leptospiral mutagenesis tools have been developed and explored. This work presents several proteins that mediate binding to components of the ECM, plasma, components of the complement system and cells, to gather research achievements that can be helpful in better understanding the mechanisms of leptospiral-host interactions and discuss genetic manipulation for Leptospira spp. aimed at protein function validation.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.extent777709pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofFrontiers in Cellular and Infection Microbiologypt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleA review on host-leptospira interactions: what we know and future expectationspt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3389/fcimb.2021.777709pt_BR
dc.identifier.urlhttps://doi.org/10.3389/fcimb.2021.777709pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.identifier.citationvolume11pt_BR
dc.subject.keywordleptospiral proteinspt_BR
dc.subject.keywordhost-pathogen interactionspt_BR
dc.subject.keywordextracellular matrix componentspt_BR
dc.subject.keywordleptospiral mutagenesis toolspt_BR
dc.subject.keywordcadherinspt_BR
dc.subject.keywordcomponents of complement systempt_BR
dc.subject.keywordplasminogen-plasminpt_BR
dc.subject.keywordfibrinogenpt_BR
dc.relation.ispartofabbreviatedFront Cell Infect Microbiolpt_BR
dc.identifier.citationabntv. 11, 777709, nov. 2021pt_BR
dc.identifier.citationvancouver2021 Nov;11:777709pt_BR
dc.contributor.butantanDaroz, Brenda|:Desvinculado|:(LDV) Lab. de Desenvolvimento de Vacinas|:PrimeiroAutorpt_BR
dc.contributor.butantanFernandes, Luis Guilherme Vírgílio|:Desvinculado|:(LDV) Lab. de Desenvolvimento de Vacinaspt_BR
dc.contributor.butantanPereira, Maria Fernanda Cavenague|:Desvinculado|:(LDV) Lab. de Desenvolvimento de Vacinaspt_BR
dc.contributor.butantanKochi, Leandro Toshio|:Desvinculado|:(LDV) Lab. de Desenvolvimento de Vacinaspt_BR
dc.contributor.butantanPassalia, Felipe José|:Desvinculado|:(LDV) Lab. de Desenvolvimento de Vacinaspt_BR
dc.contributor.butantanTakahashi, Maria Beatriz|:Desvinculado|:(LDV) Lab. de Desenvolvimento de Vacinaspt_BR
dc.contributor.butantanFilho, Edson Galdino do Nascimento|:Desvinculado|:(LDV) Lab. de Desenvolvimento de Vacinaspt_BR
dc.contributor.butantanTeixeira, Aline Rodrigues Florêncio|:Desvinculado|:(LDV) Lab. de Desenvolvimento de Vacinaspt_BR
dc.contributor.butantanNascimento, Ana Lúcia Tabet Oller do|:Pesquisador|:(LDV) Lab. de Desenvolvimento de Vacinas|:Autor de correspondênciapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/17488-2pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2016/11541-0pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/08131-0pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/09652-4pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/06201-1pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/06731-8pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/01102-2pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/26223-7pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/21959-8pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦301229/2017-1pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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