Lack of evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spillover in free-living neotropical non-human primates, Brazil
Faculdade de Medicina de São José do Rio Preto (FAMERP) ; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD) ; Universidade do Estado do Amazonas (UEA) ; Universidade Federal do Amazonas (UFAM) ; (USP) Universidade de São Paulo ; Hospital Israelita Albert Einstein ; New Mexico State University ; University of Texas Medical Branch (UTMB) ; Instituto Leônidas & Maria Deane (ILMD/Fiocruz Amazônia) ; Departamento de Vigilância Epidemiológica de São José do Rio Preto
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent of coronavirus disease 2019 (COVID-19), is responsible for the worst pandemic of the 21st century. Like all human coronaviruses, SARS-CoV-2 originated in a wildlife reservoir, most likely from bats. As SARS-CoV-2 has spread across the globe in humans, it has spilled over to infect a variety of non-human animal species in domestic, farm, and zoo settings. Additionally, a broad range of species, including one neotropical monkey, have proven to be susceptible to experimental infection with SARS-CoV-2. Together, these findings raise the specter of establishment of novel enzootic cycles of SARS-CoV-2. To assess the potential exposure of free-living non-human primates to SARS-CoV-2, we sampled 60 neotropical monkeys living in proximity to Manaus and São José do Rio Preto, two hotspots for COVID-19 in Brazil. Our molecular and serological tests detected no evidence of SAR-CoV-2 infection among these populations. While this result is reassuring, sustained surveillance efforts of wildlife living in close association with human populations is warranted, given the stochastic nature of spillover events and the enormous implications of SARS-CoV-2 spillover for human health.
Sacchetto L, Chaves BA, Costa ER, Medeiros ASM, Gordo M, Araújo DB, et al. Lack of evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spillover in free-living neotropical non-human primates, Brazil. Viruses. 2021 Sept;13(10):1933. doi:10.3390/v13101933.
Link to cite this reference
(CREATE-NEO) Coordinating Research on Emerging Arboviral Threats Encompassing the Neotropics ; (NIH) National Institutes of Health ; (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo ; (CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior ; (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico
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