Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves

Full metadata record
DC FieldValueLanguage
dc.contributor(LG) Laboratório de Genéticapt_BR
dc.contributor.authorBueris, Vanessapt_BR
dc.contributor.authorSellera, Fábio P.pt_BR
dc.contributor.authorFuga, Brunapt_BR
dc.contributor.authorSano, Elderpt_BR
dc.contributor.authorCarvalho, Marcelo P. N.pt_BR
dc.contributor.authorCouto, Samuel Campanelli Freitaspt_BR
dc.contributor.authorMoura, Quéziapt_BR
dc.contributor.authorLincopan, Niltonpt_BR
dc.date.accessioned2022-04-20T19:04:22Z-
dc.date.available2022-04-20T19:04:22Z-
dc.date.issued2022pt_BR
dc.identifier.citationBueris V, Sellera FP., Fuga B, Sano E, Carvalho MP.N., Couto SCF, et al. Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves. Sci. Rep. 2022 Apr;12:5707. doi:10.1038/s41598-022-09598-8.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/4305-
dc.description.abstractThe global spread of critical-priority antimicrobial-resistant Enterobacterales by food is a public health problem. Wild-caught seafood are broadly consumed worldwide, but exposure to land-based pollution can favor their contamination by clinically relevant antimicrobial-resistant bacteria. As part of the Grand Challenges Explorations: New Approaches to Characterize the Global Burden of Antimicrobial Resistance Program, we performed genomic surveillance and cell culture-based virulence investigation of WHO critical priority Enterobacterales isolated from marine bivalves collected in the Atlantic Coast of South America. Broad-spectrum cephalosporin-resistant Klebsiella pneumoniae and Escherichia coli isolates were recovered from eight distinct geographical locations. These strains harbored blaCTX-M-type or blaCMY-type genes. Most of the surveyed genomes confirmed the convergence of wide virulome and resistome (i.e., antimicrobials, heavy metals, biocides, and pesticides resistance). We identified strains belonging to the international high-risk clones K. pneumoniae ST307 and E. coli ST131 carrying important virulence genes, whereas in vitro experiments confirmed the high virulence potential of these strains. Thermolabile and thermostable toxins were identified in some strains, and all of them were biofilm producers. These data point to an alarming presence of resistance and virulence genes in marine environments, which may favor horizontal gene transfer and the spread of these traits to other bacterial species.pt_BR
dc.description.sponsorshipBill & Melinda Gates Foundationpt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.extent5707pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofScientific Reportspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleConvergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalvespt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.1038/s41598-022-09598-8pt_BR
dc.identifier.urlhttps://doi.org/10.1038/s41598-022-09598-8pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.external(UNIMES) Universidade Metropolitana de Santospt_BR
dc.contributor.external(UFMG) Universidade Federal de Minas Geraispt_BR
dc.identifier.citationvolume12pt_BR
dc.relation.ispartofabbreviatedSci. Reppt_BR
dc.identifier.citationabntv. 12, 5707, abr. 2022pt_BR
dc.identifier.citationvancouver2022 Apr;12:5707pt_BR
dc.contributor.butantanBueris, Vanessa|:Desvinculado|:Lab. Genética|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanCouto, Samuel Campanelli Freitas|:Desvinculado|:Lab. Genéticapt_BR
dc.sponsorship.butantanBill & Melinda Gates Foundation¦¦OPP1193112pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/08224-9pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦443819/2018-1pt_BR
dc.sponsorship.butantanCNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦312249/2017-9pt_BR
dc.sponsorship.butantanCNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦433128/2018-6pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.grantfulltextopen-
item.languageiso639-1English-
item.fulltextCom Texto completo-
item.openairetypeArticle-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journalissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journaleissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
Appears in Collections:Artigos de periódicos


Files in This Item:

s41598-022-09598-8.pdf
Description:
Size: 4.17 MB
Format: Adobe PDF
View/Open
Show simple item record

This item is licensed under a Creative Commons License Creative Commons