A comparative study of endogenous phospholipase A2 inhibitors in the serum of Brazilian pit vipers

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dc.contributorLab. Herpetologiapt_BR
dc.contributor.authorKavazoi, Victor Koitipt_BR
dc.contributor.authorSilva, Caroline Serinopt_BR
dc.contributor.authorFabri, Carolinept_BR
dc.contributor.authorHatakeyama, Daniela Mikipt_BR
dc.contributor.authorSouza, Daniel Carvalho dept_BR
dc.contributor.authorGrego, Kathleen Fernandespt_BR
dc.contributor.authorMorais-Zani, Karen dept_BR
dc.contributor.authorTanaka-Azevedo, Anita Miticopt_BR
dc.date.accessioned2022-05-02T17:23:59Z-
dc.date.available2022-05-02T17:23:59Z-
dc.date.issued2022pt_BR
dc.identifier.citationKavazoi VK, Silva CS, Fabri C, Hatakeyama DM, Souza DC, Grego KF, et al. A comparative study of endogenous phospholipase A2 inhibitors in the serum of Brazilian pit vipers. Toxicon. 2022 Apr; 213:87-91. doi:10.1016/j.toxicon.2022.04.011.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/4314-
dc.description.abstractThis work compared the presence of phospholipase A2 inhibitors (PLIs) in the serum of 19 snake species maintained at Instituto Butantan to better understand the mechanisms of venom resistance in snakes and improve the treatment of snakebite. PLI was isolated from blood of 19 snake species by one-step chromatography and identified in all samples, besides its identity was confirmed through the interaction with both phospholipase A2 and anti-γPLI. These findings highlight the diversity of snake serum PLIs and emphasize the importance of structure-function studies.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.extent87-91pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxiconpt_BR
dc.rightsRestricted accesspt_BR
dc.titleA comparative study of endogenous phospholipase A2 inhibitors in the serum of Brazilian pit viperspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.toxicon.2022.04.011pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.toxicon.2022.04.011pt_BR
dc.contributor.external(IPT) Instituto de Pesquisa Tecnológica do Estado de São Paulopt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.identifier.citationvolume213pt_BR
dc.subject.keywordPhospholipase A2pt_BR
dc.subject.keywordPhospholipase A2 inhibitorspt_BR
dc.subject.keywordsnakebitept_BR
dc.subject.keywordnatural resistancept_BR
dc.relation.ispartofabbreviatedToxiconpt_BR
dc.identifier.citationabntv. 213, p. 87-91, abr. 2022pt_BR
dc.identifier.citationvancouver2022 Apr; 213:87-91pt_BR
dc.contributor.butantanKavazoi, Victor Koiti|:Aluno|:Lab. Herpetologiapt_BR
dc.contributor.butantanSilva, Caroline Serino|:Aluno Egresso|:Lab. Herpetologiapt_BR
dc.contributor.butantanFabri, Caroline|:Aluno Egresso|:Lab. Herpetologiapt_BR
dc.contributor.butantanHatakeyama, Daniela Miki|:Aluno|:Lab. Herpetologiapt_BR
dc.contributor.butantanSouza, Daniel Carvalho de|:Aluno Egresso|:Lab. Herpetologiapt_BR
dc.contributor.butantanGrego, Kathleen Fernandes|:Pesquisador|:Lab. Herpetologiapt_BR
dc.contributor.butantanMorais-Zani, Karen de|:Pesquisador|:Lab. Herpetologiapt_BR
dc.contributor.butantanTanaka-Azevedo, Anita Mitico|:Pesquisador|:Lab. Herpetologiapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.sponsorship.butantan2018/25,786–0pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.sponsorship.butantan2017/17,165–3pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.sponsorship.butantan2017/16,908–2pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.sponsorship.butantan405399/2018–9pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.sponsorship.butantan140,872/2019–1)pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.grantfulltextembargo_20990101-
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item.languageiso639-1English-
item.openairetypeArticle-
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