Linking SOX3, SRY, and disorders of neurodevelopment

Butantan affiliation
Publication type
Book chapter
Access rights
Restricted access
Appears in Collections:
SRY and SOX3 proteins are transcription factors from the SOX family. All the SOX genes contain a structurally homologous HMG domain sequence that binds and regulates DNA. In different literature examples, it has been shown that this HMG box is functionally interchangeable between SRY and other SOX proteins. In this chapter, we review actions and interactions of SOX3 and SRY in brain tissue and possible contributions to neurodevelopment. We suggest that, at early stages of neurodevelopment, the action of both transcription factors on the same gene targets and/or coactivators could interfere in cell fate decisions, rendering alterations in brain development. Thereby, boys will be more vulnerable to toxic stress exposition and/or other genetic factors acting on the epigenetic regulation of SRY and/or SOX3 proteins as well as acting on their gene targets.
Link to cite this reference
Issue Date

Files in This Item:

Existing users please Login
Size: 1.23 MB
Format: Adobe PDF
Embargoed until January 1, 2099    Request a copy
Show full item record

The access to the publications deposited in this repository respects the licenses from journals and publishers.