Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom


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Article
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English
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Open access
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Abstract
Tb II-I isolated from Tityus bahiensis venom causes epileptic-discharges when injected into the hippocampus of rats. The involvement of neurotransmitters in this activity was investigated. Our results demonstrated that Tb II-I increases the concentrations of dopamine metabolite but does not alter other neurotransmitters. Thus, dopaminergic system seems to be partially responsible for the convulsive process. Specific action on particular neurotransmitter can make this toxin a useful tool to better understand the functioning of the system.
Reference
Beraldo Neto E, Lebrun I, Nencioni ALA. Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom. Toxicon X. 2022 Sep; 15:100126. doi:10.1016/j.toxcx.2022.100126.
Link to cite this reference
https://repositorio.butantan.gov.br/handle/butantan/4383
URL
https://doi.org/10.1016/j.toxcx.2022.100126
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Issue Date
2022


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