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Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom

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dc.contributorLab. Bioquímicapt_BR
dc.contributorLab. Farmacologiapt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.authorBeraldo Neto, Emidiopt_BR
dc.contributor.authorLebrun, Ivopt_BR
dc.contributor.authorNencioni, Ana Leonor Abrahãopt_BR
dc.date.accessioned2022-06-09T13:55:23Z-
dc.date.available2022-06-09T13:55:23Z-
dc.date.issued2022pt_BR
dc.identifier.citationBeraldo Neto E, Lebrun I, Nencioni ALA. Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom. Toxicon X. 2022 Sep; 15:100126. doi:10.1016/j.toxcx.2022.100126.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/4383-
dc.description.abstractTb II-I isolated from Tityus bahiensis venom causes epileptic-discharges when injected into the hippocampus of rats. The involvement of neurotransmitters in this activity was investigated. Our results demonstrated that Tb II-I increases the concentrations of dopamine metabolite but does not alter other neurotransmitters. Thus, dopaminergic system seems to be partially responsible for the convulsive process. Specific action on particular neurotransmitter can make this toxin a useful tool to better understand the functioning of the system.pt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.extent100126pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxicon Xpt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/pt_BR
dc.titleDopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venompt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BY-NC-NDpt_BR
dc.identifier.doi10.1016/j.toxcx.2022.100126pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.toxcx.2022.100126pt_BR
dc.identifier.citationvolume15pt_BR
dc.subject.keywordneurotoxinpt_BR
dc.subject.keywordTityus bahiensispt_BR
dc.subject.keywordHippocampuspt_BR
dc.subject.keywordneurotransmitterspt_BR
dc.subject.keyworddopaminergic systempt_BR
dc.relation.ispartofabbreviatedToxicon Xpt_BR
dc.identifier.citationabntv. 15, 100126, set. 2022pt_BR
dc.identifier.citationvancouver2022 Sep; 15:100126pt_BR
dc.contributor.butantanBeraldo Neto, Emidio|:Pesquisador|:Lab. Bioquímica|:Primeiro Autorpt_BR
dc.contributor.butantanLebrun, Ivo|:Pesquisador|:Docente PPGTOX|:Lab. Bioquímica|:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.butantanNencioni, Ana Leonor Abrahão|:Pesquisador|:Docente PPGTOX|:Lab. Farmacologia|:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)|:Autor de correspondênciapt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦AUX-PE-Toxinologia-1207/2011pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.grantfulltextopen-
item.languageiso639-1English-
item.fulltextCom Texto completo-
crisitem.journal.journalissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journaleissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
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crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid0000-0001-6978-442X-
crisitem.author.orcid0000-0002-1162-4201-
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