Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats


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Article
Language
English
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Open access
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CC BY
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Abstract
There is a high incidence of non-obese type 2 diabetes mellitus (non-obese-T2DM) cases, particularly in Asian countries, for which the pathogenesis remains mainly unclear. Interestingly, Goto-Kakizaki (GK) rats spontaneously develop insulin resistance (IR) and non-obese-T2DM, making them a lean diabetes model. Physical exercise is a non-pharmacological therapeutic approach to reduce adipose tissue mass, improving peripheral IR, glycemic control, and quality of life in obese animals or humans with T2DM. In this narrative review, we selected and analyzed the published literature on the effects of physical exercise on the metabolic features associated with non-obese-T2DM. Only randomized controlled trials with regular physical exercise training, freely executed physical activity, or skeletal muscle stimulation protocols in GK rats published after 2008 were included. The results indicated that exercise reduces plasma insulin levels, increases skeletal muscle glycogen content, improves exercise tolerance, protects renal and myocardial function, and enhances blood oxygen flow in GK rats
Reference
B.S.M.G, T.D.A.S, L.E.R, R.M, R.G, L.N.M, et al. Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats. Braz. J. Med. Biol. Res.. 2022 Set; 55:1-14. doi:10.1590/1414-431X2022e11795.
Link to cite this reference
https://repositorio.butantan.gov.br/handle/butantan/4390
URL
https://doi.org/10.1590/1414-431X2022e11795
Issue Date
2022


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