Respiratory epithelial cells: more than just a physical barrier to fungal infections

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dc.contributorLab. de Toxinologia Aplicadapt_BR
dc.contributorCeTICS - Centro de Toxinas, Resposta-imune e Sinalização Celularpt_BR
dc.contributor.authorBarros, Bianca Carla Silva Campitelli dept_BR
dc.contributor.authorAlmeida, Bruna R.pt_BR
dc.contributor.authorBarros, Debora T. L.pt_BR
dc.contributor.authorToledo, Marcos S.pt_BR
dc.contributor.authorSuzuki, Erikapt_BR
dc.date.accessioned2022-06-23T18:14:06Z-
dc.date.available2022-06-23T18:14:06Z-
dc.date.issued2022pt_BR
dc.identifier.citationBarros BCSC, Almeida BR., Barros DT.L., Toledo MS., Suzuki E. Respiratory epithelial cells: more than just a physical barrier to fungal infections. J. Fungi. 2022 May;8(6):548. doi:10.3390/jof8060548.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/4404-
dc.description.abstractThe respiratory epithelium is highly complex, and its composition varies along the conducting airways and alveoli. In addition to their primary function in maintaining the respiratory barrier and lung homeostasis for gas exchange, epithelial cells interact with inhaled pathogens, which can manipulate cell signaling pathways, promoting adhesion to these cells or hosting tissue invasion. Moreover, pathogens (or their products) can induce the secretion of chemokines and cytokines by epithelial cells, and in this way, these host cells communicate with the immune system, modulating host defenses and inflammatory outcomes. This review will focus on the response of respiratory epithelial cells to two human fungal pathogens that cause systemic mycoses: Aspergillus and Paracoccidioides. Some of the host epithelial cell receptors and signaling pathways, in addition to fungal adhesins or other molecules that are responsible for fungal adhesion, invasion, or induction of cytokine secretion will be addressed in this review.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.extent548pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofJournal of Fungipt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleRespiratory epithelial cells: more than just a physical barrier to fungal infectionspt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3390/jof8060548pt_BR
dc.identifier.urlhttps://doi.org/10.3390/jof8060548pt_BR
dc.contributor.external(UNIFESP) Universidade Federal de São Paulopt_BR
dc.identifier.citationvolume8pt_BR
dc.identifier.citationissue6pt_BR
dc.subject.keywordepithelial cellpt_BR
dc.subject.keywordrespiratorypt_BR
dc.subject.keywordlungpt_BR
dc.subject.keywordairwaypt_BR
dc.subject.keywordAspergilluspt_BR
dc.subject.keywordParacoccidioidespt_BR
dc.subject.keywordcytokinept_BR
dc.subject.keywordadhesionpt_BR
dc.subject.keywordinvasionpt_BR
dc.relation.ispartofabbreviatedJ. Fungipt_BR
dc.identifier.citationabntv. 8, n. 6, 548, maio. 2022pt_BR
dc.identifier.citationvancouver2022 May;8(6):548pt_BR
dc.contributor.butantanBarros, Bianca Carla Silva Campitelli de|:Desvinculado|:Lab. de Toxinologia Aplicada:CeTICS - Centro de Toxinas, Resposta-imune e Sinalização Celular|:PrimeiroAutorpt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/26693-9pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦170209/2018-0pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦88887.670584/2022-00pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.fulltextCom Texto completo-
item.languageiso639-1English-
item.grantfulltextopen-
item.openairetypeArticle-
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