Plasmablast expansion following the tetravalent, live-attenuated dengue vaccine Butantan-DV in DENV-Naïve and DENV-exposed individuals in a Brazilian cohort

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dc.contributorCentro de Ensaios Clínicos e Farmacovigilânciapt_BR
dc.contributor.authorSilveira, Cássia G. T.pt_BR
dc.contributor.authorMagnani, Diogo M.pt_BR
dc.contributor.authorCosta, Priscilla R.pt_BR
dc.contributor.authorAvelino-Silva, Vivian I.pt_BR
dc.contributor.authorRicciardi, Michael J.pt_BR
dc.contributor.authorTimenetsky, Maria do Carmo S. T.pt_BR
dc.contributor.authorGoulart, Raphaellapt_BR
dc.contributor.authorCorreia, Carolina A.pt_BR
dc.contributor.authorMarmorato, Mariana P.pt_BR
dc.contributor.authorFerrari, Lilianpt_BR
dc.contributor.authorNakagawa, Zelinda B.pt_BR
dc.contributor.authorTomiyama, Claudiapt_BR
dc.contributor.authorTomiyama, Helenapt_BR
dc.contributor.authorKalil, Jorgept_BR
dc.contributor.authorPalacios, Ricardopt_BR
dc.contributor.authorPrecioso, Alexander Robertopt_BR
dc.contributor.authorWatkins, David I.pt_BR
dc.contributor.authorKallás, Esper G.pt_BR
dc.date.accessioned2022-07-22T18:03:42Z-
dc.date.available2022-07-22T18:03:42Z-
dc.date.issued2022pt_BR
dc.identifier.citationSilveira CG.T., Magnani DM., Costa PR., Avelino-Silva VI., Ricciardi MJ., Timenetsky MCS.T., et al. Plasmablast expansion following the tetravalent, live-attenuated dengue vaccine Butantan-DV in DENV-Naïve and DENV-exposed individuals in a Brazilian cohort. Front. Immunol. 2022 June;13:908398. doi:10.3389/fimmu.2022.908398.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/4438-
dc.description.abstractAn effective vaccine against the dengue virus (DENV) should induce a balanced, long-lasting antibody (Ab) response against all four viral serotypes. The burst of plasmablasts in the peripheral blood after vaccination may reflect enriched vaccine-specific Ab secreting cells. Here we characterize the acute plasmablast responses from naïve and DENV-exposed individuals following immunization with the live attenuated tetravalent (LAT) Butantan DENV vaccine (Butantan-DV). The frequency of circulating plasmablasts was determined by flow cytometric analysis of fresh whole blood specimens collected from 40 participants enrolled in the Phase II Butantan-DV clinical trial (NCT01696422) before and after (days 6, 12, 15 and 22) vaccination. We observed a peak in the number of circulating plasmablast at day 15 after vaccination in both the DENV naïve and the DENV-exposed vaccinees. DENV-exposed vaccinees experienced a significantly higher plasmablast expansion. In the DENV-naïve vaccinees, plasmablasts persisted for approximately three weeks longer than among DENV-exposed volunteers. Our findings indicate that the Butantan-DV can induce plasmablast responses in both DENV-naïve and DENV-exposed individuals and demonstrate the influence of pre-existing DENV immunity on Butantan DV-induced B-cell responses.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(BNDES) Banco Nacional de Desenvolvimento Econômico e Socialpt_BR
dc.description.sponsorship(NIAID) National Institute of Allergy and Infectious Diseasespt_BR
dc.description.sponsorship(NIH) National Institutes of Healthpt_BR
dc.format.extent908398pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofFrontiers in Immunologypt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titlePlasmablast expansion following the tetravalent, live-attenuated dengue vaccine Butantan-DV in DENV-Naïve and DENV-exposed individuals in a Brazilian cohortpt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3389/fimmu.2022.908398pt_BR
dc.identifier.urlhttps://doi.org/10.3389/fimmu.2022.908398pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.externalUniversity of Miami Miller School of Medicinept_BR
dc.contributor.external(IAL) Instituto Adolfo Lutzpt_BR
dc.identifier.citationvolume13pt_BR
dc.subject.keyworddenguept_BR
dc.subject.keyworddengue infectionpt_BR
dc.subject.keyworddengue vaccinept_BR
dc.subject.keywordplasmablastpt_BR
dc.subject.keywordhumoral responsept_BR
dc.relation.ispartofabbreviatedFront Immunolpt_BR
dc.identifier.citationabntv. 13, 908398, jun. 2022pt_BR
dc.identifier.citationvancouver2022 June;13:908398pt_BR
dc.contributor.butantanPalacios, Ricardo|:Desvinculado|:Centro de Ensaios Clínicos e Farmacovigilânciapt_BR
dc.contributor.butantanPrecioso, Alexander Roberto|:Pesquisador|:Centro de Ensaios Clínicos e Farmacovigilânciapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2015/03933-3pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦pt_BR
dc.sponsorship.butantan(BNDES) Banco Nacional de Desenvolvimento Econômico e Social¦¦pt_BR
dc.sponsorship.butantan(NIAID) National Institute of Allergy and Infectious Diseases¦¦pt_BR
dc.sponsorship.butantan(NIH) National Institutes of Health¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
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