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A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine

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dc.contributorCentro Bioindustrialpt_BR
dc.contributor(LEDM) Lab. Estratégico de Diagnóstico Molecularpt_BR
dc.contributor.authorGimenes, G. M.pt_BR
dc.contributor.authorSantana, G. O.pt_BR
dc.contributor.authorScervino, M.V. M.pt_BR
dc.contributor.authorCuri, Ruipt_BR
dc.contributor.authorPereira, Joice Naiara Bertagliapt_BR
dc.date.accessioned2022-08-30T18:41:25Z-
dc.date.available2022-08-30T18:41:25Z-
dc.date.issued2022pt_BR
dc.identifier.citationGimenes G.M., Santana G.O., Scervino M.V.M., Curi R, Pereira JNB. A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine. Braz J Med Biol Res. 2022 Jun; 55:e11910. doi:10.1590/1414-431X2022e11910.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/4489-
dc.description.abstractThe Goto-Kakizaki (GK) rat is a non-obese experimental model of type 2 diabetes mellitus (T2DM) that allows researchers to monitor diabetes-induced changes without jeopardizing the effects of obesity. This rat strain exhibits notable gastrointestinal features associated with T2DM, such as marked alterations in intestinal morphology, reduced intestinal motility, slow transit, and modified microbiota compared to Wistar rats. The primary treatments for diabetic patients include administration of hypoglycemic agents and insulin, and lifestyle changes. Emerging procedures, including alternative therapies, metabolic surgeries, and modulation of the intestinal microbiota composition, have been shown to improve the diabetic state of GK rats. This review describes the morpho-physiological diabetic-associated features of the gastrointestinal tract (GIT) of GK rats. We also describe promising strategies, e.g., metabolic surgery and modulation of gut microbiota composition, used to target the GIT of this animal model to improve the diabetic state.pt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.extente11910pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofBrazilian Journal of Medical and Biological Researchpt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleA short review on the features of the non-obese diabetic Goto-Kakizaki rat intestinept_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.1590/1414-431X2022e11910pt_BR
dc.contributor.external(UNICSUL) Universidade Cruzeiro do Sulpt_BR
dc.identifier.citationvolume55pt_BR
dc.subject.keyworddiabetes treatmentpt_BR
dc.subject.keywordgastrointestinal tractpt_BR
dc.subject.keywordGK ratspt_BR
dc.subject.keywordintestinal microbiotapt_BR
dc.subject.keywordtype 2 diabetespt_BR
dc.relation.ispartofabbreviatedBraz J Med Biol Respt_BR
dc.identifier.citationabntv. 55, e11910, jun. 2022pt_BR
dc.identifier.citationvancouver2022 Jun; 55:e11910pt_BR
dc.contributor.butantanCuri, Rui|:Outros|:Centro Bioindustrialpt_BR
dc.contributor.butantanPereira, Joice Naiara Bertaglia|:Técnico|:(LEDM) Lab. Estratégico de Diagnóstico Molecularpt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/09868-7pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/01942-6pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019-02175-9pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/19097-0pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.fulltextCom Texto completo-
item.openairetypeArticle-
item.languageiso639-1English-
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