Método de conjugação de polissacarídeo capsular a uma proteína carregadora, para uso como antígeno vacinal contra bactérias encapsuladas, utilizando o reagente cloreto de 4-(4,6-dimetoxi-1,3,5-triazin-2-il)-4-metilmorfolino (dmtmm)

Abstract

Consists of a method of conjugation between capsular polysaccharide and protein to obtain vaccine antigen, and the conjugation step is mediated by the reagent 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)- 4-methylmorpholino (DMT-MM) consisting of an innovation in the process of obtaining vaccine antigens.