Humoral and cellular immune responses to CoronaVac up to one year after vaccination

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dc.contributorCentro de Ensaios Clínicos e Farmacovigilânciapt_BR
dc.contributor.authorCosta, Priscilla Ramospt_BR
dc.contributor.authorCorreia, Carolina Argondizopt_BR
dc.contributor.authorMarmorato, Mariana Pradopt_BR
dc.contributor.authorPatiño, Elizabeth Gonzálezpt_BR
dc.identifier.citationCosta PR, Correia CA, Marmorato MP, Patiño EG. Humoral and cellular immune responses to CoronaVac up to one year after vaccination. Front Immunol. 2022 Oct; 13:1032411. doi:10.3389/fimmu.2022.1032411.pt_BR
dc.description.abstractCoronavac is a widely used SARS-CoV-2 inactivated vaccine, but its long-term immune response assessment is still lacking. We evaluated SARS-CoV-2-specific immune responses, including T cell activation markers, antigen-specific cytokine production and antibody response following vaccination in 53 adult and elderly individuals participating in a phase 3 clinical trial. Activated follicular helper T (Tfh), non-Tfh and memory CD4+ T cells were detected in almost all subjects early after the first vaccine dose. Activated memory CD4+ T cells were predominantly of central and effector memory T cell phenotypes and were sustained for at least 6 months. We also detected a balanced Th1-, Th2- and Th17/Th22-type cytokine production that was associated with response over time, together with particular cytokine profile linked to poor responses in older vaccinees. SARS-CoV-2-specific IgG levels peaked 14 days after the second dose and were mostly stable over one year. CoronaVac was able to induce a potent and durable antiviral antigen-specific cellular response and the cytokine profiles related to the response over time and impacted by the senescence were defined.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(NIH) National Institutes of Healthpt_BR
dc.description.sponsorshipBill & Melinda Gates Foundationpt_BR
dc.description.sponsorship(USP) Universidade de São Paulopt_BR
dc.relation.ispartofFrontiers in Immunologypt_BR
dc.rightsOpen accesspt_BR
dc.titleHumoral and cellular immune responses to CoronaVac up to one year after vaccinationpt_BR
dc.rights.licenseCC BYpt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.externalLa Jolla Institute for Immunologypt_BR
dc.contributor.externalUniversity of California, San Diegopt_BR
dc.contributor.externalPATH USpt_BR
dc.subject.keywordcellular responsept_BR
dc.subject.keywordhumoral responsept_BR
dc.subject.keywordimmune memorypt_BR
dc.relation.ispartofabbreviatedFront Immunolpt_BR
dc.identifier.citationabntv. 13, 1032411, out. 2022pt_BR
dc.identifier.citationvancouver2022 Oct; 13:1032411pt_BR
dc.contributor.butantanPatiño, Elizabeth González|:Outros|:Centro de Ensaios Clínicos e Farmacovigilânciapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/10127-1pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/06409-1pt_BR
dc.sponsorship.butantan(NIH) National Institutes of Health¦¦75N93019C00065pt_BR
dc.sponsorship.butantanBill & Melinda Gates Foundation¦¦INV-021239pt_BR
dc.sponsorship.butantan(HC/HCFMUSP) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo¦¦HCCOMVIDApt_BR
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