Anticoagulants from Hematophagous

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dc.contributor(LDI) Lab. Desenvolvimento e Inovação Industrialpt_BR
dc.contributor.authorChudzinski-Tavassi, Ana Marisapt_BR
dc.contributor.authorFaria, Fernandapt_BR
dc.contributor.authorFlores, Miryam Paola Alvarezpt_BR
dc.contributor.editorMojca Božič-Mijovskipt_BR
dc.description.abstractThis chapter will focus on anticoagulant molecules described until now from hematophagous animals. The evolutionary scenario for hematophagous animals is convergent and has resulted on a wide diversity of saliva anticoagulants, substances with platelet anti-aggregation action, and also with vase-dilating action. Hematophagous animals such as bloodsuckers (leeches, mosquitoes, and ticks) have developed strategies that specifically target proteinases from the hemostatic system of the animals they feed, thus keeping the blood incoagulable. The saliva of those animals provides a large amount of molecules to modulate the innate immune response of the host and to inhibit blood coagulation in order to facilitate the feeding. Thus, anticoagulants from hematophagous animals represent a very interesting tool for studies ranging from basic research to applications in the therapeutic area, as anticoagulant medication. Several studies have pointed out that anticoagulants from hematophagous can also display non-hemostatic functions as anti-tumor, bringing new perspectives for the study of these molecules. The comprehension of the multi-faced physiological roles of those new anticoagulants from hematophagous opens new perspectives for therapeutic and biotechnological approaches.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.rightsOpen accesspt_BR
dc.titleAnticoagulants from Hematophagouspt_BR
dc.typeBook chapterpt_BR
dc.rights.licenseCC BYpt_BR
dc.subject.keywordhematophagous animalspt_BR
dc.subject.keywordblood coagulationpt_BR
dc.subject.keywordFXa inhibitorpt_BR
dc.subject.keywordthrombin inhibitorpt_BR
dc.contributor.butantanChudzinski-Tavassi, Ana Marisa|:Pesquisador|:(LDI) Lab. Desenvolvimento e Inovação Industrial|:Primeiro Autor|:Autor de correspondênciapt_BR
dc.contributor.butantanFaria, Fernanda|:Pesquisador|:(LDI) Lab. Desenvolvimento e Inovação Industrialpt_BR
dc.contributor.butantanFlores, Miryam Paola Alvarez|:Técnico|:(LDI) Lab. Desenvolvimento e Inovação Industrialpt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2015/50040-4pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2013/07467-1pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦305445/2023-8pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦480703/2013-2pt_BR
dc.relation.ispartofbookAnticoagulant Drugspt_BR
item.fulltextCom Texto completo-
item.openairetypeBook chapter-
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