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Molecular identification of the emerging human Gemykibivirus-2 (HuGkV-2) among Brazilian blood donors

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dc.contributor(NUTERA-RP) Núcleo de Terapia Celular Avançadapt_BR
dc.contributorDiretoria Técnicapt_BR
dc.contributor.authorZucherato, Victória Simionattopt_BR
dc.contributor.authorGiovanetti, Martapt_BR
dc.contributor.authorCosta, Lara Okuyama Afonsopt_BR
dc.contributor.authorCovas, Dimas Tadeupt_BR
dc.contributor.authorSlavov, Svetoslav Nanevpt_BR
dc.date.accessioned2023-02-16T18:10:08Z-
dc.date.available2023-02-16T18:10:08Z-
dc.date.issued2023pt_BR
dc.identifier.citationZucherato VS, Giovanetti M, Costa LOA, Covas DT, Slavov SN. Molecular identification of the emerging human Gemykibivirus-2 (HuGkV-2) among Brazilian blood donors. Transfus. Apher. Sci.. 2023 Feb; 62(1):103516. doi:10.1016/j.transci.2022.103516.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/4798-
dc.description.abstractHuman gemykibivirus-2 (HuGkV-2) belonging to the Gemykibivirus genus (Genomoviridae family) is an emerging DNA virus which has been described as a component of the virome of a wide variety of samples including clinical ones. So far, the HuGkV-2 DNA prevalence in the human population as well as its clinical impact are completely unknown. The objective of this study was to investigate the HuGkV-2 DNA prevalence among Brazilian healthy blood donors from three different geographic regions. A total of 450 blood samples were screened for HuGkV-2 DNA (150 samples were from the Brazilian Amazon, 150 from Midwest Brazil and 150 from South Brazil). The overall HuGkV-2 DNA prevalence was 7.8 %. Considering the examined regions, the highest prevalence was observed in the Brazilian Amazon (city of Macapa, state of Amapa), 15.3 %, followed by the Midwest Brazil (city of Brasilia, Federal District) (6.0 %) and South Brazil (city of Santa Maria, Rio Grande do Sul State) (2.0 %). This study gives preliminary insights on the molecular prevalence of HuGkV-2 DNA among Brazilian blood donors, highlighting that the highest HuGkV-2 prevalence was recorded in the Brazilian Amazon. However, more studies regarding the prevalence, transmission routes and any possible clinical effects appear to be crucial in order to understand the impact of this emerging viral agent.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(AIRC) Associazione Italiana per la Ricerca sul Cancropt_BR
dc.description.sponsorship(FAPERJ) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiropt_BR
dc.format.extent103516pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofTransfusion and Apheresis Sciencept_BR
dc.rightsRestricted accesspt_BR
dc.titleMolecular identification of the emerging human Gemykibivirus-2 (HuGkV-2) among Brazilian blood donorspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.transci.2022.103516pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.transci.2022.103516pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.external(FIOCRUZ) Fundação Oswaldo Cruzpt_BR
dc.contributor.externalUniversity of Campus Bio-Medico di Romapt_BR
dc.contributor.external(UFSM) Universidade Federal de Santa Mariapt_BR
dc.contributor.external(UNIEURO) Centro Universitário Euro Americanopt_BR
dc.contributor.external(UNB) Universidade de Brasíliapt_BR
dc.contributor.externalInstituto de Hematologia e Hemoterapia do Amapápt_BR
dc.identifier.citationvolume62pt_BR
dc.identifier.citationissue1pt_BR
dc.subject.keywordhuman Gemykbivirus-2pt_BR
dc.subject.keywordHuGkV-2pt_BR
dc.subject.keywordprevalencept_BR
dc.subject.keywordBrazilpt_BR
dc.subject.keywordblood donorspt_BR
dc.relation.ispartofabbreviatedTransfus Apher Scipt_BR
dc.identifier.citationabntv. 62, n. 1, 103516, fev. 2023pt_BR
dc.identifier.citationvancouver2023 Feb; 62(1):103516pt_BR
dc.contributor.butantanCovas, Dimas Tadeu|:Outros|:Diretoria Técnica|:pt_BR
dc.contributor.butantanSlavov, Svetoslav Nanev|:Pesquisador|:(NUTERA-RP) Núcleo de Terapia Celular Avançada|:Autor de correspondência|:pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/23205-8pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/15826-5pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/13194-1pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2021/09446-8pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2021/10595-8pt_BR
dc.sponsorship.butantan(AIRC) Associazione Italiana per la Ricerca sul Cancro¦¦Ricerca e Innovazione¦¦2014-2020pt_BR
dc.sponsorship.butantan(FAPERJ) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro¦¦E-26/202.248/2018pt_BR
dc.sponsorship.butantan(FAPERJ) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro¦¦E26/202.665/2019pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
dc.description.internalPolítica de depósito: liberado apenas preprintpt_BR
item.openairetypeArticle-
item.fulltextSem Texto completo-
item.grantfulltextnone-
item.languageiso639-1English-
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